Profile of the Portfolio of NIH-Funded HIV Implementation Research Projects to Inform Ending the HIV Epidemic Strategies

Artur Queiroz, Melissa Mongrella, Brennan Keiser, Dennis H. Li, Nanette Benbow, Brian Mustanski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background:The US government created an initiative to end the HIV epidemic in the United States by the year 2030 (EHE). This multiagency initiative was structured around four pillars: Prevent, Diagnose, Treat, and Respond to improve HIV programs, resources, and service delivery infrastructure. In support of its research mission, the National Institutes of Health (NIH) has funded implementation research (IR) projects by addressing the four pillars and encouraging investigators to collaborate with local partners and Health and Human Services (HHS) grantees in 57 priority jurisdictions.Methods:This paper analyzed data from the NIH funded CFAR/ARC supplement projects from 2019 to 2021. The Exploration, Preparation, Implementation, Sustainment (EPIS) framework was used to characterize projects by stage of implementation.Results:The Prevent pillar was most frequently studied, with Pre-Exposure Prophylaxis (PrEP) being the most studied intervention. The most common partners were health departments, community-based organizations (CBOs), and Federally Qualified Health Centers (FQHCs). The Consolidated Framework for Implementation Research (CFIR) framework was the most utilized to investigate implementation determinants, followed by the RE-AIM framework and Proctor model to assess implementation outcomes.Conclusion:Monitoring the projects resulting from NIH investments is fundamental to understanding the response to EHE, and achieving these results requires systematic and continuous effort that can support the generalizable implementation knowledge emerging from individual studies. There are some remaining gaps in the project portfolio, including geographical coverage, range of implementation outcomes being measured, and interventions still requiring further research to ensure equitable scale-up of evidence based interventions and achieve EHE goals.

Original languageEnglish (US)
Pages (from-to)S23-S31
JournalJournal of Acquired Immune Deficiency Syndromes
Volume90
DOIs
StatePublished - Jul 1 2022

Funding

This work was made possible through a supplement grant to the Third Coast Center for AIDS Research (CFAR), an NIH funded center (P30 AI117943). The content is solely the responsibility of the authors and does not necessarily reflect the official views of the NIH. The Implementation Science Coordination Initiative (ISCI; HIVimpsci.northwestern.edu ) provides scientific support and coordination for implementation research (IR) projects funded by the National Institutes of Health (NIH), primarily through its Centers for AIDS Research and AIDS Research Centers (CFAR/ARCs). Since 2019, NIH has funded 117 unique CFAR/ARC supplement projects, with 65 1-year planning projects in the first year. In the second year, 34 projects were funded, comprising new 1-year projects and 12 ongoing projects that received 2 years of additional funding. In the third year, 36 new 1-year projects were funded.

Keywords

  • Ending the HIV Epidemic
  • implementation science
  • portfolio analysis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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