TY - JOUR
T1 - Profiling Immune Expression to Consider Repurposing Therapeutics for the Ichthyoses
AU - Paller, Amy S.
PY - 2019/3
Y1 - 2019/3
N2 - Despite extensive discovery about the mutations underlying genetic skin disorders, there have been few therapeutic advances. Better understanding of the molecular changes that may lead to the phenotypic manifestations of genetic disorders may lead to the discovery of new pharmacologic interventions. The ichthyoses are characterized by scaling, inflammation, and an impaired epidermal barrier. Recent studies have uncovered T helper type 17 skewing in ichthyotic skin, resembling psoriasis, and high frequencies of IL-17– and IL-22–expressing T cells in blood, correlating with severity and transepidermal water loss. Repurposing systemic T helper type 17/IL-23–inhibitory therapies for psoriasis may prove useful for patients with ichthyosis.
AB - Despite extensive discovery about the mutations underlying genetic skin disorders, there have been few therapeutic advances. Better understanding of the molecular changes that may lead to the phenotypic manifestations of genetic disorders may lead to the discovery of new pharmacologic interventions. The ichthyoses are characterized by scaling, inflammation, and an impaired epidermal barrier. Recent studies have uncovered T helper type 17 skewing in ichthyotic skin, resembling psoriasis, and high frequencies of IL-17– and IL-22–expressing T cells in blood, correlating with severity and transepidermal water loss. Repurposing systemic T helper type 17/IL-23–inhibitory therapies for psoriasis may prove useful for patients with ichthyosis.
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U2 - 10.1016/j.jid.2018.08.027
DO - 10.1016/j.jid.2018.08.027
M3 - Review article
C2 - 30670307
AN - SCOPUS:85060083303
VL - 139
SP - 535
EP - 540
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 3
ER -