Profiling the liver graft

Stela Celaj, Josh Levitsky*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Purpose of review Achieving operational tolerance remains a priority in liver transplantation. Although several biomarkers of tolerance and rejection have been identified, few have been reproducible and validated across centers, and therefore have yet to reach clinical practice. Here we summarize findings from prior seminal studies and review current developments in profiling the liver allograft. Recent findings Substantial efforts and progress have been made in the recent years towards the discovery of reliable biomarkers that can predict and guide successful immunosuppression withdrawal. Recent studies have also investigated the transcriptomic signatures underlying not only acute rejection but also subclinical inflammation and chronic allograft injury. Summary As new genomic and sequencing technologies continue to develop, clinical trials are underway to validate biomarkers of tolerance, as well as better understand the mechanisms of both acute and subclinical rejection, with the goal of maximizing allograft survival. Altogether, this will hopefully enable the implementation of immunosuppression withdrawal protocols into clinical practice and make operational tolerance reliably attainable in the near future.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalCurrent opinion in organ transplantation
Volume26
Issue number1
DOIs
StatePublished - Feb 2021

Keywords

  • Biomarkers
  • Immunosuppression withdrawal
  • Liver transplantation
  • Operational tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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