Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target

Keyphrases

• Stem Cells 100%
• DNA Methylation (DNAm) 100%
• Uterine Leiomyoma 100%
• Putative Drug Targets 100%
• Progesterone Receptor 100%
• Leiomyoma 50%
• Antiprogestins 50%
• Leiomyoma Cells 50%
• Tumor 33%
• Stem Cell Differentiation 33%
• Progesterone 33%
• Cell Population 16%
• Gene Expression 16%
• Transcriptome 16%
• Knockdown 16%
• Cistrome 16%
• Tumor Size 16%
• Paracrine Signaling 16%
• Treatment Cessation 16%
• DNA Methyltransferase Inhibitor 16%
• Feedback Loop 16%
• Gene Locus 16%
• Progesterone Signaling 16%
• 5-azacytidine 16%
• Hypermethylated 16%
• Global DNA Methylation 16%
• Primary Leiomyosarcoma 16%
• Rapid Differentiation 16%
• Tumor Regrowth 16%
• Methylcytosine Dioxygenase 16%

Medicine and Dentistry

• Stem Cell 100%
• Uterine Fibroid 100%
• Progesterone Receptor 100%
• DNA Methylation 100%
• Angioleiomyoma 75%
• Neoplasm 50%
• Antigestagen 37%
• Progesterone 37%
• Cell Differentiation 25%
• Receptor 12%
• Cell Population 12%
• Gene Locus 12%
• Minoxidil 12%
• Transcriptome 12%
• Paracrine Signalling 12%
• Dioxygenase 12%

Biochemistry, Genetics and Molecular Biology

• Stem Cell 100%
• DNA Methylation 100%
• Progesterone Receptor 100%
• Progesterone 37%
• Cellular Differentiation 25%
• Dioxygenase 12%
• Tumor Volume 12%
• Paracrine Signalling 12%
• Gene Locus 12%
• Minoxidil 12%
• Transcriptome 12%