Prognostic factors for functional outcome of total knee replacement: A prospective study

Leena Sharma*, James Sinacore, Claire Daugherty, Daniel T. Kuesis, S. David Stulberg, Marjorie Lewis, Gerhard Baumann, Rowland W. Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Background. The objective was to investigate whether baseline physical functioning, medical, psychosocial, or demographic variables predict functional outcome in patients undergoing total knee replacement. Methods. A prospective cohort study was performed between December 1991 and August 1993. Consecutive, unilateral tricompartmental total knee replacement patients aged ≤55 yr with osteoarthritis, who met criteria, were enrolled and evaluated one month before and 3 months after total knee replacement. The primary outcome measure was the Medical Outcome Study 36 Item Short Form Health Survey (known as the SF36) Physical Functioning Scale score. The outcome evaluator was not involved in patient care. Results. A hierarchical multiple regression analysis was performed to calculate the contribution of baseline variables to TKR outcome. Of the 27% of outcome variance explained by the model, demographic variables accounted for 4%, psychosocial variables (motivation, role functioning-emotional, and social functioning) for 19% (p = .013), medical variables (previous reconstruction, comorbidity, body mass index, bodily pain) for 2%, and baseline physical function for 2%. Conclusions. Psychosocial variables are significantly related to total knee replacement functional outcome. Assessment of baseline psychological and social functioning may identify a subset of patients at risk for worse outcome. Specific interventions for these patients should be developed and evaluated as components of patient management prior to and after the procedure.

Original languageEnglish (US)
Pages (from-to)M152-M157
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number4
StatePublished - Jul 1996

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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