Prognostic Factors for Survival in Melanoma Patients with Brain Metastases

Isabella C. Glitza*, Amy B. Heimberger, Erik P. Sulman, Michael A. Davies

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations


Melanoma is the most aggressive form of skin cancer. One of the most common and devastating complications of advanced melanoma is the development of metastases to the central nervous system (CNS). Historically outcomes in patients with melanoma brain metastases have been dismal. However, an improved understanding of the molecular pathogenesis of this disease has recently led to the development of multiple new therapies with unprecedented clinical efficacy, generating optimism that significant improvements in long-term patient survival are achievable. Achieving this goal will require improved prevention and treatment of CNS metastases. To set the stage for the appropriate design and interpretation of clinical trials in this area, this chapter will review and integrate existing data about clinical and molecular factors that predict the development, survival, and treatment outcomes of melanoma patients with brain metastases.

Original languageEnglish (US)
Title of host publicationBrain Metastases from Primary Tumors
Subtitle of host publicationEpidemiology, Biology, and Therapy of Melanoma and Other Cancers
PublisherElsevier Inc
Number of pages31
ISBN (Electronic)9780128035597
ISBN (Print)9780128035085
StatePublished - Apr 27 2016
Externally publishedYes


  • Brain metastases
  • Central nervous system (CNS)
  • Melanoma
  • Radiation
  • Skin cancer
  • Surgery
  • Systemic treatment

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Prognostic Factors for Survival in Melanoma Patients with Brain Metastases'. Together they form a unique fingerprint.

Cite this