Prognostic factors in human immunodeficiency virus-positive patients with a cd4 lymphocyte count <50/µl

Elizabeth G. Apolonio*, Donald R. Hoover, Yanhua He, Alfred J. Saah, David W. Lyter, Roger Detels, Richard A. Kaslow, John P. Phair

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

This analysis investigated variability of survival time in a cohort of 553 human immunodeficiency virus type 1 (HIV-1)-infected homosexual or bisexual men with <50 CD4+ cells/µL Median survival after the first CD4+ cell count <50/µL was 1.34 years; 25% survived 2 years. Multivariate analysis showed longer survival with concurrent acyclovir and zidovudine use, hemoglobin 12 g/dL, and full-time employment (P <.0001). Other significant covariates associated with longer survival included African-American race, no prior AIDS illness, weight loss <4.5 kg, and zidovudine use (with or without concurrent acyclovir) after CD4+ cells fell to <50/µL. An easily derived score identified Multicenter AIDS Cohort Study subjects likely to survive >2 years after CD4+ cell count was <50/µL. Survival once CD4+ cell count fell below 50/µL may be longer for persons with a good performance status and specific clinical markers. Health care providers should consider these variables in decision-making strategies and design of clinical trials.

Original languageEnglish (US)
Pages (from-to)829-836
Number of pages8
JournalJournal of Infectious Diseases
Volume171
Issue number4
DOIs
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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