Prognostic usefulness of the walter reed staging classification for hiv infection

Keith B. Macdonell; Joan S. Chmiel; Joanne Goldsmith; Carl Bertil Wallemark; James Steinberg; Elaine Byers; John P. Phair

Prognostic usefulness of the walter reed staging classification for hiv infection

Keith B. Macdonell^*, Joan S. Chmiel, Joanne Goldsmith, Carl Bertil Wallemark, James Steinberg, Elaine Byers, John P. Phair

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We evaluated the usefulness of both the Walter Reed (WR) staging classification and the component criteria used in the system in predicting progression to AIDS. The WR classification was applied to a cohort of 431 men who were seropositive for the human immunodeficiency virus on entry into a prospective study. The WR classification was of limited usefulness, as only 133 men (31%) could be assigned to a WR stage. Among men who could be WR classified, only individuals in WR stage 5 were found to have a significantly more rapid progression to AIDS. The seropositive cohort was also classified based on initial CD4 cell number. Low CD4 counts (<400 cells/mm³) were significantly associated with progression to AIDS, and grouping seropositive men by CD4 number alone provided as much prognostic information as the WR classification. Skin test anergy was also asignificant predictor for progression to AIDS, but only in individuals with low CD4 counts.

Original language	English (US)
Pages (from-to)	367-374
Number of pages	8
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	1
Issue number	4
State	Published - Aug 1988

Keywords

CD4 cells
Classification system
Disease progression
HIV infection
Lymphadenopathy
Skin testing

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Prognostic usefulness of the walter reed staging classification for hiv infection",

abstract = "We evaluated the usefulness of both the Walter Reed (WR) staging classification and the component criteria used in the system in predicting progression to AIDS. The WR classification was applied to a cohort of 431 men who were seropositive for the human immunodeficiency virus on entry into a prospective study. The WR classification was of limited usefulness, as only 133 men (31%) could be assigned to a WR stage. Among men who could be WR classified, only individuals in WR stage 5 were found to have a significantly more rapid progression to AIDS. The seropositive cohort was also classified based on initial CD4 cell number. Low CD4 counts (<400 cells/mm3) were significantly associated with progression to AIDS, and grouping seropositive men by CD4 number alone provided as much prognostic information as the WR classification. Skin test anergy was also asignificant predictor for progression to AIDS, but only in individuals with low CD4 counts.",

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author = "Macdonell, {Keith B.} and Chmiel, {Joan S.} and Joanne Goldsmith and Wallemark, {Carl Bertil} and James Steinberg and Elaine Byers and Phair, {John P.}",

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language = "English (US)",

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journal = "Journal of Acquired Immune Deficiency Syndromes",

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T1 - Prognostic usefulness of the walter reed staging classification for hiv infection

AU - Macdonell, Keith B.

AU - Chmiel, Joan S.

AU - Goldsmith, Joanne

AU - Wallemark, Carl Bertil

AU - Steinberg, James

AU - Byers, Elaine

AU - Phair, John P.

PY - 1988/8

Y1 - 1988/8

N2 - We evaluated the usefulness of both the Walter Reed (WR) staging classification and the component criteria used in the system in predicting progression to AIDS. The WR classification was applied to a cohort of 431 men who were seropositive for the human immunodeficiency virus on entry into a prospective study. The WR classification was of limited usefulness, as only 133 men (31%) could be assigned to a WR stage. Among men who could be WR classified, only individuals in WR stage 5 were found to have a significantly more rapid progression to AIDS. The seropositive cohort was also classified based on initial CD4 cell number. Low CD4 counts (<400 cells/mm3) were significantly associated with progression to AIDS, and grouping seropositive men by CD4 number alone provided as much prognostic information as the WR classification. Skin test anergy was also asignificant predictor for progression to AIDS, but only in individuals with low CD4 counts.

AB - We evaluated the usefulness of both the Walter Reed (WR) staging classification and the component criteria used in the system in predicting progression to AIDS. The WR classification was applied to a cohort of 431 men who were seropositive for the human immunodeficiency virus on entry into a prospective study. The WR classification was of limited usefulness, as only 133 men (31%) could be assigned to a WR stage. Among men who could be WR classified, only individuals in WR stage 5 were found to have a significantly more rapid progression to AIDS. The seropositive cohort was also classified based on initial CD4 cell number. Low CD4 counts (<400 cells/mm3) were significantly associated with progression to AIDS, and grouping seropositive men by CD4 number alone provided as much prognostic information as the WR classification. Skin test anergy was also asignificant predictor for progression to AIDS, but only in individuals with low CD4 counts.

KW - CD4 cells

KW - Classification system

KW - Disease progression

KW - HIV infection

KW - Lymphadenopathy

KW - Skin testing

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Prognostic usefulness of the walter reed staging classification for hiv infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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