Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study

David D. McManus; Sanjiv J. Shah; Mary Rose Fabi; Alisa Rosen; Mary A. Whooley; Nelson B. Schiller

doi:10.1016/j.echo.2008.11.005

Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study

David D. McManus, Sanjiv J. Shah, Mary Rose Fabi, Alisa Rosen, Mary A. Whooley, Nelson B. Schiller^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Objective: Left ventricular (LV) end-systolic volume indexed to body surface area (ESVI) is a simple yet powerful echocardiographic marker of LV remodeling that can be measured easily. The prognostic value of ESVI and its merit relative to other markers of LV remodeling in patients with coronary heart disease are unknown. Methods: We examined the association of ESVI with hospitalization for heart failure (HF) and mortality in a prospective study of patients with coronary heart disease. Results: Of the 989 participants, 110 (11%) were hospitalized for HF during 3.6 ± 1.1 years of follow-up. Among participants in the highest ESVI quartile (>25 mL/m²), 67 of 248 (27%) developed HF compared with 8 of 248 (3%) among those in the lowest quartile. The association between ESVI and HF hospitalization persisted after adjustment for potential confounders (hazard ratio 5.0, 95% confidence interval, 1.5-16.9; P = .01). Conclusion: ESVI >25 mL/m² is an independent predictor of hospitalization for HF in patients with stable coronary heart disease.

Original language	English (US)
Pages (from-to)	190-197
Number of pages	8
Journal	Journal of the American Society of Echocardiography
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.echo.2008.11.005
State	Published - Feb 2009

Keywords

Coronary artery disease
End-systolic volume index
Heart failure hospitalization
Left ventricular remodeling

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

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10.1016/j.echo.2008.11.005

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McManus, D. D., Shah, S. J., Fabi, M. R., Rosen, A., Whooley, M. A., & Schiller, N. B. (2009). Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study. Journal of the American Society of Echocardiography, 22(2), 190-197. https://doi.org/10.1016/j.echo.2008.11.005

@article{3b5075f651e4486da51facefeb946769,

title = "Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study",

abstract = "Objective: Left ventricular (LV) end-systolic volume indexed to body surface area (ESVI) is a simple yet powerful echocardiographic marker of LV remodeling that can be measured easily. The prognostic value of ESVI and its merit relative to other markers of LV remodeling in patients with coronary heart disease are unknown. Methods: We examined the association of ESVI with hospitalization for heart failure (HF) and mortality in a prospective study of patients with coronary heart disease. Results: Of the 989 participants, 110 (11%) were hospitalized for HF during 3.6 ± 1.1 years of follow-up. Among participants in the highest ESVI quartile (>25 mL/m2), 67 of 248 (27%) developed HF compared with 8 of 248 (3%) among those in the lowest quartile. The association between ESVI and HF hospitalization persisted after adjustment for potential confounders (hazard ratio 5.0, 95% confidence interval, 1.5-16.9; P = .01). Conclusion: ESVI >25 mL/m2 is an independent predictor of hospitalization for HF in patients with stable coronary heart disease.",

keywords = "Coronary artery disease, End-systolic volume index, Heart failure hospitalization, Left ventricular remodeling",

author = "McManus, {David D.} and Shah, {Sanjiv J.} and Fabi, {Mary Rose} and Alisa Rosen and Whooley, {Mary A.} and Schiller, {Nelson B.}",

note = "Funding Information: Financial Disclosures: The Heart and Soul Study was supported by grants from the Department of Veterans Affairs (Epidemiology Program), Robert Wood Johnson Foundation, American Federation for Aging Research, and National Institutes of Health (R01 HL079235 ). Dr Shah was supported by a Heart Failure Society of America Research Fellowship Award. ",

year = "2009",

month = feb,

doi = "10.1016/j.echo.2008.11.005",

language = "English (US)",

volume = "22",

pages = "190--197",

journal = "Journal of the American Society of Echocardiography",

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McManus, DD, Shah, SJ, Fabi, MR, Rosen, A, Whooley, MA & Schiller, NB 2009, 'Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study', Journal of the American Society of Echocardiography, vol. 22, no. 2, pp. 190-197. https://doi.org/10.1016/j.echo.2008.11.005

Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study. / McManus, David D.; Shah, Sanjiv J.; Fabi, Mary Rose et al.
In: Journal of the American Society of Echocardiography, Vol. 22, No. 2, 02.2009, p. 190-197.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease

T2 - Data from the Heart and Soul Study

AU - McManus, David D.

AU - Shah, Sanjiv J.

AU - Fabi, Mary Rose

AU - Rosen, Alisa

AU - Whooley, Mary A.

AU - Schiller, Nelson B.

N1 - Funding Information: Financial Disclosures: The Heart and Soul Study was supported by grants from the Department of Veterans Affairs (Epidemiology Program), Robert Wood Johnson Foundation, American Federation for Aging Research, and National Institutes of Health (R01 HL079235 ). Dr Shah was supported by a Heart Failure Society of America Research Fellowship Award.

PY - 2009/2

Y1 - 2009/2

N2 - Objective: Left ventricular (LV) end-systolic volume indexed to body surface area (ESVI) is a simple yet powerful echocardiographic marker of LV remodeling that can be measured easily. The prognostic value of ESVI and its merit relative to other markers of LV remodeling in patients with coronary heart disease are unknown. Methods: We examined the association of ESVI with hospitalization for heart failure (HF) and mortality in a prospective study of patients with coronary heart disease. Results: Of the 989 participants, 110 (11%) were hospitalized for HF during 3.6 ± 1.1 years of follow-up. Among participants in the highest ESVI quartile (>25 mL/m2), 67 of 248 (27%) developed HF compared with 8 of 248 (3%) among those in the lowest quartile. The association between ESVI and HF hospitalization persisted after adjustment for potential confounders (hazard ratio 5.0, 95% confidence interval, 1.5-16.9; P = .01). Conclusion: ESVI >25 mL/m2 is an independent predictor of hospitalization for HF in patients with stable coronary heart disease.

AB - Objective: Left ventricular (LV) end-systolic volume indexed to body surface area (ESVI) is a simple yet powerful echocardiographic marker of LV remodeling that can be measured easily. The prognostic value of ESVI and its merit relative to other markers of LV remodeling in patients with coronary heart disease are unknown. Methods: We examined the association of ESVI with hospitalization for heart failure (HF) and mortality in a prospective study of patients with coronary heart disease. Results: Of the 989 participants, 110 (11%) were hospitalized for HF during 3.6 ± 1.1 years of follow-up. Among participants in the highest ESVI quartile (>25 mL/m2), 67 of 248 (27%) developed HF compared with 8 of 248 (3%) among those in the lowest quartile. The association between ESVI and HF hospitalization persisted after adjustment for potential confounders (hazard ratio 5.0, 95% confidence interval, 1.5-16.9; P = .01). Conclusion: ESVI >25 mL/m2 is an independent predictor of hospitalization for HF in patients with stable coronary heart disease.

KW - Coronary artery disease

KW - End-systolic volume index

KW - Heart failure hospitalization

KW - Left ventricular remodeling

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DO - 10.1016/j.echo.2008.11.005

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EP - 197

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

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ER -

Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study

Abstract

Keywords

ASJC Scopus subject areas

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