Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients

Matthijs Van Kranenburg, Michael Magro, Holger Thiele, Suzanne DeWaha, Ingo Eitel, Alexandre Cochet, Yves Cottin, Dan Atar, Peter Buser, Edwin Wu, Daniel Lee, Vicente Bodi, Gert Klug, Bernhard Metzler, Ronak Delewi, Peter Bernhardt, Wolfgang Rottbauer, Eric Boersma, Felix Zijlstra, Robert Jan Van Geuns*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

162 Scopus citations

Abstract

The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (IS%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV $25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE.

Original languageEnglish (US)
Pages (from-to)930-939
Number of pages10
JournalJACC: Cardiovascular Imaging
Volume7
Issue number9
DOIs
StatePublished - 2014

Keywords

  • Cardiac magnetic resonance
  • Infarct size
  • Microvascular obstruction
  • Myocardial infarction
  • Prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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