Programmable Matter: The Nanoparticle Atom and DNA Bond

Devleena Samanta, Wenjie Zhou, Sasha B. Ebrahimi, Sarah Hurst Petrosko, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Colloidal crystal engineering with DNA has led to significant advances in bottom-up materials synthesis and a new way of thinking about fundamental concepts in chemistry. Here, programmable atom equivalents (PAEs), comprised of nanoparticles (the “atoms”) functionalized with DNA (the “bonding elements”), are assembled through DNA hybridization into crystalline lattices. Unlike atomic systems, the “atom” (e.g., the nanoparticle shape, size, and composition) and the “bond” (e.g., the DNA length and sequence) can be tuned independently, yielding designer materials with unique catalytic, optical, and biological properties. In this review, nearly three decades of work that have contributed to the evolution of this class of programmable matter is chronicled, starting from the earliest examples based on gold-core PAEs, and then delineating how advances in synthetic capabilities, DNA design, and fundamental understanding of PAE-PAE interactions have led to new classes of functional materials that, in several cases, have no natural equivalent.

Original languageEnglish (US)
Article number2107875
JournalAdvanced Materials
Volume34
Issue number12
DOIs
StatePublished - Mar 24 2022

Keywords

  • DNA
  • colloidal crystal engineering
  • nanoparticles
  • programmable atom equivalent
  • spherical nucleic acids

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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