Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions

Jiaojiao Wu, Peng Ning, Rui Gao, Qishuai Feng, Yajing Shen, Yifan Zhang, Yingze Li, Chang Xu, Yao Qin, Gustavo R. Plaza, Qianwen Bai, Xing Fan, Zhenguang Li, Yu Han, Maciej S. Lesniak, Haiming Fan, Yu Cheng*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Reactive oxygen species (ROS), a group of oxygen derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe and deep-tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for precise cancer treatment. Here, a mechanical-thermal induction therapy (MTIT) strategy is developed for a programmable increase of ROS levels in cancer cells via assembly of magnetic nanocubes integrated with alternating magnetic fields. The magneto-based mechanical and thermal stimuli can disrupt the lysosomes, which sequentially induce the dysfunction of mitochondria. Importantly, intracellular ROS concentrations are responsive to the magneto-triggers and play a key role for synergistic cancer treatment. In vivo experiments reveal the effectiveness of MTIT for efficient eradication of glioma and breast cancer. By remote control of the force and heat using magnetic nanocubes, MTIT is a promising physical approach to trigger the biochemical responses for precise cancer treatment.

Original languageEnglish (US)
Article number1902933
JournalAdvanced Science
Volume7
Issue number12
DOIs
StatePublished - Jun 1 2020

Keywords

  • cancer treatment
  • magnetic fields
  • magnetic nanoparticles
  • reactive oxygen species
  • synergistic effects

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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  • Cite this

    Wu, J., Ning, P., Gao, R., Feng, Q., Shen, Y., Zhang, Y., Li, Y., Xu, C., Qin, Y., Plaza, G. R., Bai, Q., Fan, X., Li, Z., Han, Y., Lesniak, M. S., Fan, H., & Cheng, Y. (2020). Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions. Advanced Science, 7(12), [1902933]. https://doi.org/10.1002/advs.201902933