TY - JOUR
T1 - Progranulin (GRN) in two siblings of a Latino family and in other patients with Schizophrenia
AU - Momeni, Parastoo
AU - DeTucci, Karen
AU - Straub, Richard E.
AU - Weinberger, Daniel R.
AU - Davies, Peter
AU - Grafman, Jordan
AU - Hardy, John
AU - Huey, Edward D.
N1 - Funding Information:
This study was supported by the intramural programs of The National Institutes of Health/The National Institute of Neurological Disorders and Stroke/The National Institute on Aging/The National Institute of Mental Health, NINDS grant 1K99NS060766-01 (EDH), and the Litwin-Zucker Center for Research on Alzheimer’s Disease and Memory Disorders (EDH). We thank Pablo V. Gejman for providing us with DNA samples from schizophrenia patients, Eric Wassermann for neurological examinations, the NINDS Clinical Center nurses for patient care, the assistance of the community physicians involved in the care of the patients, and all of the subjects for their generous participation. None of the authors have any potential conflicts of interest to disclose.
PY - 2010/6
Y1 - 2010/6
N2 - Schizophrenia has been linked to a region on chromosome 17q21 in Latino populations (Escamilla et al., 2009). Mutations of a gene at this location (GRN) are associated with frontotemporal dementia. A recent study demonstrated that patients with frontotemporal dementia who presented with symptoms of schizophrenia show neuropathological findings consistent with GRN mutations, but were not tested for GRN mutations (Velakoulis, Walterfang, Mocellin, Pantelis, & McLean, 2009). The current study describes a Latino family in which two siblings have schizophrenia and one has frontotemporal dementia. We sequenced GRN in one of the siblings with frontotemporal dementia and one of the siblings with schizophrenia. The siblings both have a loss-of-function GRN mutation. This finding, in conjunction with other studies (Escamilla et al., 2009; Velakoulis et al., 2009), suggests that there may be an association between schizophrenia, frontotemporal dementia, and GRN mutations in Latino populations that should be investigated further.
AB - Schizophrenia has been linked to a region on chromosome 17q21 in Latino populations (Escamilla et al., 2009). Mutations of a gene at this location (GRN) are associated with frontotemporal dementia. A recent study demonstrated that patients with frontotemporal dementia who presented with symptoms of schizophrenia show neuropathological findings consistent with GRN mutations, but were not tested for GRN mutations (Velakoulis, Walterfang, Mocellin, Pantelis, & McLean, 2009). The current study describes a Latino family in which two siblings have schizophrenia and one has frontotemporal dementia. We sequenced GRN in one of the siblings with frontotemporal dementia and one of the siblings with schizophrenia. The siblings both have a loss-of-function GRN mutation. This finding, in conjunction with other studies (Escamilla et al., 2009; Velakoulis et al., 2009), suggests that there may be an association between schizophrenia, frontotemporal dementia, and GRN mutations in Latino populations that should be investigated further.
KW - Frontotemporal dementia
KW - Genetics
KW - Progranulin
KW - Psychiatric disorders
KW - Schizophrenia
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U2 - 10.1080/13554790903456209
DO - 10.1080/13554790903456209
M3 - Article
C2 - 20087814
AN - SCOPUS:77952921864
VL - 16
SP - 273
EP - 279
JO - Neurocase
JF - Neurocase
SN - 1355-4794
IS - 3
ER -