Progranulin (GRN) in two siblings of a Latino family and in other patients with Schizophrenia

Parastoo Momeni*, Karen DeTucci, Richard E. Straub, Daniel R. Weinberger, Peter Davies, Jordan Grafman, John Hardy, Edward D. Huey

*Corresponding author for this work

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Schizophrenia has been linked to a region on chromosome 17q21 in Latino populations (Escamilla et al., 2009). Mutations of a gene at this location (GRN) are associated with frontotemporal dementia. A recent study demonstrated that patients with frontotemporal dementia who presented with symptoms of schizophrenia show neuropathological findings consistent with GRN mutations, but were not tested for GRN mutations (Velakoulis, Walterfang, Mocellin, Pantelis, & McLean, 2009). The current study describes a Latino family in which two siblings have schizophrenia and one has frontotemporal dementia. We sequenced GRN in one of the siblings with frontotemporal dementia and one of the siblings with schizophrenia. The siblings both have a loss-of-function GRN mutation. This finding, in conjunction with other studies (Escamilla et al., 2009; Velakoulis et al., 2009), suggests that there may be an association between schizophrenia, frontotemporal dementia, and GRN mutations in Latino populations that should be investigated further.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalNeurocase
Volume16
Issue number3
DOIs
StatePublished - Jun 2010

Keywords

  • Frontotemporal dementia
  • Genetics
  • Progranulin
  • Psychiatric disorders
  • Schizophrenia

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Momeni, P., DeTucci, K., Straub, R. E., Weinberger, D. R., Davies, P., Grafman, J., Hardy, J., & Huey, E. D. (2010). Progranulin (GRN) in two siblings of a Latino family and in other patients with Schizophrenia. Neurocase, 16(3), 273-279. https://doi.org/10.1080/13554790903456209