Progress in Cleveland Clinic-Nimbus total artificial heart development

H. Harasaki; K. Fukamachi; A. Massiello; J. F. Chen; S. C. Himley; F. Fukumura; K. Muramoto; S. Niu; K. Wika; C. R. Davies; P. M. McCarthy; R. J. Kiraly; D. C. Thomas; T. C. Rintoul; J. C. Carriker; T. R. Maher; K. C. Butler

doi:10.1097/00002480-199407000-00049

Progress in Cleveland Clinic-Nimbus total artificial heart development

H. Harasaki^*, K. Fukamachi, A. Massiello, J. F. Chen, S. C. Himley, F. Fukumura, K. Muramoto, S. Niu, K. Wika, C. R. Davies, P. M. McCarthy, R. J. Kiraly, D. C. Thomas, T. C. Rintoul, J. C. Carriker, T. R. Maher, K. C. Butler

^*Corresponding author for this work

Surgery, Cardiac Surgery Division

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A totally implantable, Cleveland Clinic-Nimbus total artificial heart (TAH) uses electrohydraulic energy conversion and an automatic left master- alternate mode control scheme, with a filling sensitivity of 1.0 l/min/mmHg and a maximum output of 9.5 l/min. The TAHs were tested in 12 calves for 1- 120 days with normal major organ and blood cell function. Post-operative suppression of platelet aggregation recovered by the second post-operative week. The gelatin-coated pump surface generally was clean without any anticoagulants and free from infection. Embolism, which occurred in two cases, was caused by complications attributable to fungal infection in a Dacron graft and by thrombus formed around a jugular vein catheter. A system with a hybridized microcircuit controller in the interventricular space has been tested successfully in the three most recent cases, with a peak device surface temperature elevation of 6.5° C. Heat effects were confined to the tissues immediately adjacent to the hottest spots. The carbon fiber- reinforced epoxy housing and 60 ml butyl rubber compliance chamber showed good tissue compatibility with a thin, fibrous tissue capsule. The transcutaneous energy transmission system and the internal battery functioned well as designed in the most recent animal implant.

Original language	English (US)
Journal	ASAIO Journal
Volume	40
Issue number	3
DOIs	https://doi.org/10.1097/00002480-199407000-00049
State	Published - Jan 1 1994

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

Access to Document

10.1097/00002480-199407000-00049

Cite this

Harasaki, H., Fukamachi, K., Massiello, A., Chen, J. F., Himley, S. C., Fukumura, F., Muramoto, K., Niu, S., Wika, K., Davies, C. R., McCarthy, P. M., Kiraly, R. J., Thomas, D. C., Rintoul, T. C., Carriker, J. C., Maher, T. R., & Butler, K. C. (1994). Progress in Cleveland Clinic-Nimbus total artificial heart development. ASAIO Journal, 40(3). https://doi.org/10.1097/00002480-199407000-00049

@article{6d32f9e3d911452c82a18d105582ed11,

title = "Progress in Cleveland Clinic-Nimbus total artificial heart development",

abstract = "A totally implantable, Cleveland Clinic-Nimbus total artificial heart (TAH) uses electrohydraulic energy conversion and an automatic left master- alternate mode control scheme, with a filling sensitivity of 1.0 l/min/mmHg and a maximum output of 9.5 l/min. The TAHs were tested in 12 calves for 1- 120 days with normal major organ and blood cell function. Post-operative suppression of platelet aggregation recovered by the second post-operative week. The gelatin-coated pump surface generally was clean without any anticoagulants and free from infection. Embolism, which occurred in two cases, was caused by complications attributable to fungal infection in a Dacron graft and by thrombus formed around a jugular vein catheter. A system with a hybridized microcircuit controller in the interventricular space has been tested successfully in the three most recent cases, with a peak device surface temperature elevation of 6.5° C. Heat effects were confined to the tissues immediately adjacent to the hottest spots. The carbon fiber- reinforced epoxy housing and 60 ml butyl rubber compliance chamber showed good tissue compatibility with a thin, fibrous tissue capsule. The transcutaneous energy transmission system and the internal battery functioned well as designed in the most recent animal implant.",

author = "H. Harasaki and K. Fukamachi and A. Massiello and Chen, {J. F.} and Himley, {S. C.} and F. Fukumura and K. Muramoto and S. Niu and K. Wika and Davies, {C. R.} and McCarthy, {P. M.} and Kiraly, {R. J.} and Thomas, {D. C.} and Rintoul, {T. C.} and Carriker, {J. C.} and Maher, {T. R.} and Butler, {K. C.}",

year = "1994",

month = jan,

day = "1",

doi = "10.1097/00002480-199407000-00049",

language = "English (US)",

volume = "40",

journal = "ASAIO Journal",

issn = "1058-2916",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Progress in Cleveland Clinic-Nimbus total artificial heart development

AU - Harasaki, H.

AU - Fukamachi, K.

AU - Massiello, A.

AU - Chen, J. F.

AU - Himley, S. C.

AU - Fukumura, F.

AU - Muramoto, K.

AU - Niu, S.

AU - Wika, K.

AU - Davies, C. R.

AU - McCarthy, P. M.

AU - Kiraly, R. J.

AU - Thomas, D. C.

AU - Rintoul, T. C.

AU - Carriker, J. C.

AU - Maher, T. R.

AU - Butler, K. C.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - A totally implantable, Cleveland Clinic-Nimbus total artificial heart (TAH) uses electrohydraulic energy conversion and an automatic left master- alternate mode control scheme, with a filling sensitivity of 1.0 l/min/mmHg and a maximum output of 9.5 l/min. The TAHs were tested in 12 calves for 1- 120 days with normal major organ and blood cell function. Post-operative suppression of platelet aggregation recovered by the second post-operative week. The gelatin-coated pump surface generally was clean without any anticoagulants and free from infection. Embolism, which occurred in two cases, was caused by complications attributable to fungal infection in a Dacron graft and by thrombus formed around a jugular vein catheter. A system with a hybridized microcircuit controller in the interventricular space has been tested successfully in the three most recent cases, with a peak device surface temperature elevation of 6.5° C. Heat effects were confined to the tissues immediately adjacent to the hottest spots. The carbon fiber- reinforced epoxy housing and 60 ml butyl rubber compliance chamber showed good tissue compatibility with a thin, fibrous tissue capsule. The transcutaneous energy transmission system and the internal battery functioned well as designed in the most recent animal implant.

AB - A totally implantable, Cleveland Clinic-Nimbus total artificial heart (TAH) uses electrohydraulic energy conversion and an automatic left master- alternate mode control scheme, with a filling sensitivity of 1.0 l/min/mmHg and a maximum output of 9.5 l/min. The TAHs were tested in 12 calves for 1- 120 days with normal major organ and blood cell function. Post-operative suppression of platelet aggregation recovered by the second post-operative week. The gelatin-coated pump surface generally was clean without any anticoagulants and free from infection. Embolism, which occurred in two cases, was caused by complications attributable to fungal infection in a Dacron graft and by thrombus formed around a jugular vein catheter. A system with a hybridized microcircuit controller in the interventricular space has been tested successfully in the three most recent cases, with a peak device surface temperature elevation of 6.5° C. Heat effects were confined to the tissues immediately adjacent to the hottest spots. The carbon fiber- reinforced epoxy housing and 60 ml butyl rubber compliance chamber showed good tissue compatibility with a thin, fibrous tissue capsule. The transcutaneous energy transmission system and the internal battery functioned well as designed in the most recent animal implant.

UR - http://www.scopus.com/inward/record.url?scp=0028465438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028465438&partnerID=8YFLogxK

U2 - 10.1097/00002480-199407000-00049

DO - 10.1097/00002480-199407000-00049

M3 - Article

C2 - 8555565

AN - SCOPUS:0028465438

SN - 1058-2916

VL - 40

JO - ASAIO Journal

JF - ASAIO Journal

IS - 3

ER -

Progress in Cleveland Clinic-Nimbus total artificial heart development

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this