Progress in Cleveland Clinic-Nimbus total artificial heart development

H. Harasaki*, K. Fukamachi, A. Massiello, J. F. Chen, S. C. Himley, F. Fukumura, K. Muramoto, S. Niu, K. Wika, C. R. Davies, P. M. McCarthy, R. J. Kiraly, D. C. Thomas, T. C. Rintoul, J. C. Carriker, T. R. Maher, K. C. Butler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A totally implantable, Cleveland Clinic-Nimbus total artificial heart (TAH) uses electrohydraulic energy conversion and an automatic left master- alternate mode control scheme, with a filling sensitivity of 1.0 l/min/mmHg and a maximum output of 9.5 l/min. The TAHs were tested in 12 calves for 1- 120 days with normal major organ and blood cell function. Post-operative suppression of platelet aggregation recovered by the second post-operative week. The gelatin-coated pump surface generally was clean without any anticoagulants and free from infection. Embolism, which occurred in two cases, was caused by complications attributable to fungal infection in a Dacron graft and by thrombus formed around a jugular vein catheter. A system with a hybridized microcircuit controller in the interventricular space has been tested successfully in the three most recent cases, with a peak device surface temperature elevation of 6.5° C. Heat effects were confined to the tissues immediately adjacent to the hottest spots. The carbon fiber- reinforced epoxy housing and 60 ml butyl rubber compliance chamber showed good tissue compatibility with a thin, fibrous tissue capsule. The transcutaneous energy transmission system and the internal battery functioned well as designed in the most recent animal implant.

Original languageEnglish (US)
JournalASAIO Journal
Issue number3
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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