FORTSCHRITTE IN DER THERAPIE VON KOPF- UND HALSTUMOREN. 1. TEIL: CHEMOTHERAPIE

Translated title of the contribution: Progress in treatment of head and neck cancer. Part 1: Chemotherapy

R. Stupp*, E. E. Vokes

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Purpose: Cancer of the head and neck is commonly diagnosed in an advanced stage with a poor prognosis. New active agents and combinations have recently been identified. By adding chemotherapy to a multimodality approach with surgery and radiation therapy the outcome may be altered. Methods: We reviewed the more recently published literature on induction and adjuvant chemotherapy. Results: Four conclusive randomized trials of induction chemotherapy have failed to show an improved survival. No survival advantage has been shown for adjuvant chemotherapy. Organ preservation can be achieved with induction chemotherapy followed by limited surgery and radiation in approximately two thirds of the patients with laryngeal carcinoma. Patients achieving a complete response after induction chemotherapy have a better prognosis. Chemotherapy has consistently shown to reduce the frequency of distant metastases. Conclusion: Chemotherapy is indicated only in recurrent or metastatic disease. Induction chemotherapy is limited to laryngeal carcinoma with organ preservation as intent. Local recurrences and intercurrent morbidity are the main reasons for treatment failures.

Translated title of the contributionProgress in treatment of head and neck cancer. Part 1: Chemotherapy
Original languageGerman
Pages (from-to)12-17
Number of pages6
JournalStrahlentherapie und Onkologie
Volume171
Issue number1
StatePublished - Feb 1 1995

ASJC Scopus subject areas

  • Cancer Research
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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