Progress on Designing a Chemical Retinal Prosthesis

Jiajia Wu; Corey M. Rountree; Sai Siva Kare; Pradeep Kumar Ramkumar; John D. Finan; John B. Troy

doi:10.3389/fncel.2022.898865

Progress on Designing a Chemical Retinal Prosthesis

Jiajia Wu, Corey M. Rountree, Sai Siva Kare, Pradeep Kumar Ramkumar, John D. Finan, John B. Troy^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The last major review of progress toward a chemical retinal prosthesis was a decade ago. Many important advancements have been made since then with the aim of producing an implantable device for animal testing. We review that work here discussing the potential advantages a chemical retinal prosthesis may possess, the spatial and temporal resolutions it might provide, the materials from which an implant might be constructed and its likely effectiveness in stimulating the retina in a natural fashion. Consideration is also given to implant biocompatibility, excitotoxicity of dispensed glutamate and known changes to photoreceptor degenerate retinas.

Original language	English (US)
Article number	898865
Journal	Frontiers in Cellular Neuroscience
Volume	16
DOIs	https://doi.org/10.3389/fncel.2022.898865
State	Published - Jun 10 2022

Funding

This work was supported by NIH R21EB028069 to JF and JT.

Keywords

glutamate stimulation
neurotransmitter-based prosthesis
retinal degeneration
retinal prosthesis
retinitis pigmentosa
vision restoration

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.3389/fncel.2022.898865

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title = "Progress on Designing a Chemical Retinal Prosthesis",

abstract = "The last major review of progress toward a chemical retinal prosthesis was a decade ago. Many important advancements have been made since then with the aim of producing an implantable device for animal testing. We review that work here discussing the potential advantages a chemical retinal prosthesis may possess, the spatial and temporal resolutions it might provide, the materials from which an implant might be constructed and its likely effectiveness in stimulating the retina in a natural fashion. Consideration is also given to implant biocompatibility, excitotoxicity of dispensed glutamate and known changes to photoreceptor degenerate retinas.",

keywords = "glutamate stimulation, neurotransmitter-based prosthesis, retinal degeneration, retinal prosthesis, retinitis pigmentosa, vision restoration",

author = "Jiajia Wu and Rountree, {Corey M.} and Kare, {Sai Siva} and Ramkumar, {Pradeep Kumar} and Finan, {John D.} and Troy, {John B.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Wu, Rountree, Kare, Ramkumar, Finan and Troy.",

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doi = "10.3389/fncel.2022.898865",

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AU - Wu, Jiajia

AU - Rountree, Corey M.

AU - Kare, Sai Siva

AU - Ramkumar, Pradeep Kumar

AU - Finan, John D.

AU - Troy, John B.

PY - 2022/6/10

Y1 - 2022/6/10

N2 - The last major review of progress toward a chemical retinal prosthesis was a decade ago. Many important advancements have been made since then with the aim of producing an implantable device for animal testing. We review that work here discussing the potential advantages a chemical retinal prosthesis may possess, the spatial and temporal resolutions it might provide, the materials from which an implant might be constructed and its likely effectiveness in stimulating the retina in a natural fashion. Consideration is also given to implant biocompatibility, excitotoxicity of dispensed glutamate and known changes to photoreceptor degenerate retinas.

AB - The last major review of progress toward a chemical retinal prosthesis was a decade ago. Many important advancements have been made since then with the aim of producing an implantable device for animal testing. We review that work here discussing the potential advantages a chemical retinal prosthesis may possess, the spatial and temporal resolutions it might provide, the materials from which an implant might be constructed and its likely effectiveness in stimulating the retina in a natural fashion. Consideration is also given to implant biocompatibility, excitotoxicity of dispensed glutamate and known changes to photoreceptor degenerate retinas.

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KW - neurotransmitter-based prosthesis

KW - retinal degeneration

KW - retinal prosthesis

KW - retinitis pigmentosa

KW - vision restoration

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Progress on Designing a Chemical Retinal Prosthesis

Abstract

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Keywords

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