Progress on Designing a Chemical Retinal Prosthesis

Jiajia Wu, Corey M. Rountree, Sai Siva Kare, Pradeep Kumar Ramkumar, John D. Finan, John B. Troy*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The last major review of progress toward a chemical retinal prosthesis was a decade ago. Many important advancements have been made since then with the aim of producing an implantable device for animal testing. We review that work here discussing the potential advantages a chemical retinal prosthesis may possess, the spatial and temporal resolutions it might provide, the materials from which an implant might be constructed and its likely effectiveness in stimulating the retina in a natural fashion. Consideration is also given to implant biocompatibility, excitotoxicity of dispensed glutamate and known changes to photoreceptor degenerate retinas.

Original languageEnglish (US)
Article number898865
JournalFrontiers in Cellular Neuroscience
StatePublished - Jun 10 2022


  • glutamate stimulation
  • neurotransmitter-based prosthesis
  • retinal degeneration
  • retinal prosthesis
  • retinitis pigmentosa
  • vision restoration

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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