Progress toward the clinical application of patient-specific pluripotent stem cells

Evangelos Kiskinis*, Kevin Eggan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

272 Scopus citations

Abstract

Induced pluripotent stem (iPS) cells are generated by epigenetic reprogramming of somatic cells through the exogenous expression of transcription factors. These cells, just like embryonic stem cells, are likely to have a major impact on regenerative medicine, because they self-renew and retain the potential to be differentiated into all cell types of the human body. In this Review, we describe the current state of iPS cell technology, including approaches by which they are generated and what is known about their biology, and discuss the potential applications of these cells for disease modeling, drug discovery, and, eventually, cell replacement therapy.

Original languageEnglish (US)
Pages (from-to)51-59
Number of pages9
JournalJournal of Clinical Investigation
Volume120
Issue number1
DOIs
StatePublished - Jan 4 2010

ASJC Scopus subject areas

  • Medicine(all)

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