TY - JOUR
T1 - Progression of Glomerular and Tubular Disease in Pediatrics
AU - Woroniecki, Robert P.
AU - Schnaper, H. William
PY - 2009/7
Y1 - 2009/7
N2 - Chronic kidney disease may be stimulated by many different etiologies, but its progression involves a common, yet complex, series of events that lead to the replacement of normal tissue with scar. These events include altered physiology within the kidney leading to abnormal hemodynamics, chronic hypoxia, inflammation, cellular dysfunction, and activation of fibrogenic biochemical pathways. The end result is the replacement of normal structures with extracellular matrix. Treatments presently are focused on delaying or preventing such progression, and are largely nonspecific. In pediatrics, such therapy is complicated further by pathophysiological issues that render children a unique population.
AB - Chronic kidney disease may be stimulated by many different etiologies, but its progression involves a common, yet complex, series of events that lead to the replacement of normal tissue with scar. These events include altered physiology within the kidney leading to abnormal hemodynamics, chronic hypoxia, inflammation, cellular dysfunction, and activation of fibrogenic biochemical pathways. The end result is the replacement of normal structures with extracellular matrix. Treatments presently are focused on delaying or preventing such progression, and are largely nonspecific. In pediatrics, such therapy is complicated further by pathophysiological issues that render children a unique population.
KW - Fibrosis
KW - cytokines
KW - extracellular matrix
KW - proteinuria
KW - scar
UR - http://www.scopus.com/inward/record.url?scp=67650105256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650105256&partnerID=8YFLogxK
U2 - 10.1016/j.semnephrol.2009.03.016
DO - 10.1016/j.semnephrol.2009.03.016
M3 - Article
C2 - 19615562
AN - SCOPUS:67650105256
SN - 0270-9295
VL - 29
SP - 412
EP - 424
JO - Seminars in nephrology
JF - Seminars in nephrology
IS - 4
ER -