Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP

Sung B. Lee, Edward M. Manno, Kennith F. Layton, E. F M Wijdicks

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.

Original languageEnglish (US)
Pages (from-to)1272-1274
Number of pages3
JournalNeurology
Volume67
Issue number7
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Clinical Neurology

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