Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP

Sung B. Lee; Edward M. Manno; Kennith F. Layton; E. F M Wijdicks

doi:10.1212/01.wnl.0000238104.75563.2f

Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP

Sung B. Lee, Edward M. Manno, Kennith F. Layton, E. F M Wijdicks

Neurology

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.

Original language	English (US)
Pages (from-to)	1272-1274
Number of pages	3
Journal	Neurology
Volume	67
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000238104.75563.2f
State	Published - Oct 2006

ASJC Scopus subject areas

Clinical Neurology

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abstract = "To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.",

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AB - To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.

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Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP

Abstract

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