Progressive aortic stenosis in homozygous familial hypercholesterolemia after liver transplant

Margaret Greco, Joshua D. Robinson*, Osama Eltayeb, Irwin Benuck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Early onset coronary artery disease and aortic calcifications are characteristic features of patients with homozygous familial hypercholesterolemia. Standard medical therapy includes dietary modification, pharmacotherapy, and lipoprotein apheresis to lower serum low-density lipoprotein cholesterol (LDL-C). Liver transplant is a surgical option for the treatment of homozygous familial hypercholesterolemia and can lead to normal cholesterol levels. Vascular calcifications are known to progress despite standard medical therapy and have been reported after liver transplant in the setting of rejection. We present the first report of progressive severe aortic valve stenosis in a patient despite liver transplant with normalization of lipid levels and no history of graft rejection.

Original languageEnglish (US)
Article numbere20160740
Issue number5
StatePublished - Nov 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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