Progressive encephalopathy in children with acquired immue deficiency syndrome

Leon G. Epstien*, Leroy R. Sharer, Vijay V. Joshi, Myrna M. Fojas, M. Richard Koenigsberger, James M. Oleske

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

214 Scopus citations


We are reporting the cases of four children with a diagnosis of acquired immune deficiency syndrome (AIDS) who demonstrated a progressive encephalopathy manifested by loss of motor milestones or intellectual abilities, and weakness with pyramidal tract signs. Two patients were ataxic. One child was cortically blind and suffered myoclonic jerks before his death. Two of the patients had isolated seizures at some time during the disease course. Two patients developed secondary microcephaly and all four patients showed cortical atrophy on computed tomographic scanning. Three of the patients died. Postmortem neuropathological findings included gross cortical atorphy, microglial nodules, and intranuclear inclusions, as are described in the subacute encephalitis reported in adult AIDS patients. We propose that the possible pathogenetic mechanisms of the encephalopathy include opportunistic or persistent viral infection of the brain.

Original languageEnglish (US)
Pages (from-to)488-496
Number of pages9
JournalAnnals of neurology
Issue number5
StatePublished - May 1985

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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