Progressive Multifocal Leukoencephalopathy

Elena Grebenciucova*, Joseph R. Berger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the syndrome of PML. This article reviews PML in association with the most common immunotherapies and discusses risk mitigation and monitoring strategies.

Original languageEnglish (US)
Pages (from-to)739-750
Number of pages12
JournalNeurologic clinics
Issue number4
StatePublished - Nov 2018


  • John Cunningham virus
  • Opportunistic infection
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Clinical Neurology


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