Progressive Multifocal Leukoencephalopathy

Elena Grebenciucova; Joseph R. Berger

doi:10.1016/j.ncl.2018.06.002

Progressive Multifocal Leukoencephalopathy

Elena Grebenciucova^*, Joseph R. Berger

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the syndrome of PML. This article reviews PML in association with the most common immunotherapies and discusses risk mitigation and monitoring strategies.

Original language	English (US)
Pages (from-to)	739-750
Number of pages	12
Journal	Neurologic clinics
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.ncl.2018.06.002
State	Published - Nov 2018

Keywords

John Cunningham virus
Opportunistic infection
Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2018.06.002

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Cite this

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title = "Progressive Multifocal Leukoencephalopathy",

abstract = "Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the syndrome of PML. This article reviews PML in association with the most common immunotherapies and discusses risk mitigation and monitoring strategies.",

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