Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

Chen S. Tan, Igor J. Koralnik*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

513 Scopus citations

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal brain disease caused by reactivation of the polyomavirus JC. Knowledge of the characteristics of PML has substantially expanded since the introduction of combination antiretroviral therapy during the HIV epidemic and the development of immune reconstitution inflammatory syndrome (IRIS) in patients with PML. Recently, the monoclonal antibodies natalizumab, efalizumab, and rituximab-used for the treatment of multiple sclerosis, psoriasis, haematological malignancies, Crohn's disease, and rheumatic diseases-have been associated with PML. Additionally, the JC virus can also lead to novel neurological disorders such as JC virus granule cell neuronopathy and JC virus encephalopathy, and might also cause meningitis. The increasingly diverse populations at risk and the recent discovery of the presence of the JC virus in the grey matter invite us to reappraise the pathogenesis of this virus in the CNS.

Original languageEnglish (US)
Pages (from-to)425-437
Number of pages13
JournalThe Lancet Neurology
Volume9
Issue number4
DOIs
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Clinical Neurology

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