Progressive multifocal leukoencephalopathy in HIV-1 infection

Paola Cinque*, Igor J. Koralnik, Simonetta Gerevini, Jose M. Miro, Richard W. Price

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

169 Scopus citations


Progressive multifocal leukoencephalopathy is caused by the JC polyomavirus (JCV) and is one of the most feared complications of HIV-1 infection. Unlike other opportunistic infections, this disease can present when CD4 counts are higher than those associated with AIDS and when patients are receiving combined antiretroviral therapy, either shortly after starting or, more rarely, during long term successful treatment. Clinical suspicion of the disease is typically when MRI shows focal neurological deficits and associated demyelinating lesions; however, the identification of JCV in cerebrospinal fluid or brain tissue is needed for a definitive diagnosis. Although no specific treatment exists, the reversal of immunosuppression by combined antiretroviral therapy leads to clinical and MRI stabilisation in 50-60% of patients with the disease, and JCV clearance from cerebrospinal fluid. A substantial proportion of patients treated with combined antiretroviral therapy develop inflammatory lesions, which can be associated with either a favourable outcome or clinical worsening. The reasons for variability in the natural history of progressive multifocal leukoencephalopathy and treatment responses are largely undefined, and more specific and rational approaches to management are needed.

Original languageEnglish (US)
Pages (from-to)625-636
Number of pages12
JournalThe Lancet Infectious Diseases
Issue number10
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Infectious Diseases


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