Progressive multifocal leukoencephalopathy in pediatric patients: Case report and literature review

Hayden Schwenk; Lynn Ramirez-Avila; Shu Hsien Sheu; Christian Wuthrich; Jeff Waugh; Adam Was; Umberto Degirolami; Sandra Burchett; Igor J. Koralnik; Asim Ahmed

doi:10.1097/INF.0000000000000237

Progressive multifocal leukoencephalopathy in pediatric patients: Case report and literature review

Hayden Schwenk^*, Lynn Ramirez-Avila, Shu Hsien Sheu, Christian Wuthrich, Jeff Waugh, Adam Was, Umberto Degirolami, Sandra Burchett, Igor J. Koralnik, Asim Ahmed

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.

Original language	English (US)
Pages (from-to)	e99-e105
Journal	Pediatric Infectious Disease Journal
Volume	33
Issue number	4
DOIs	https://doi.org/10.1097/INF.0000000000000237
State	Published - Apr 2014

Keywords

Granule cell neuron
HIV
JC virus
Pediatric
Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000000237

Cite this

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title = "Progressive multifocal leukoencephalopathy in pediatric patients: Case report and literature review",

abstract = "Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.",

keywords = "Granule cell neuron, HIV, JC virus, Pediatric, Progressive multifocal leukoencephalopathy",

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T1 - Progressive multifocal leukoencephalopathy in pediatric patients

T2 - Case report and literature review

AU - Schwenk, Hayden

AU - Ramirez-Avila, Lynn

AU - Sheu, Shu Hsien

AU - Wuthrich, Christian

AU - Waugh, Jeff

AU - Was, Adam

AU - Degirolami, Umberto

AU - Burchett, Sandra

AU - Koralnik, Igor J.

AU - Ahmed, Asim

PY - 2014/4

Y1 - 2014/4

N2 - Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.

AB - Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.

KW - Granule cell neuron

KW - HIV

KW - JC virus

KW - Pediatric

KW - Progressive multifocal leukoencephalopathy

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Progressive multifocal leukoencephalopathy in pediatric patients: Case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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