Progressive optic nerve cupping and neural rim decrease in a patient with bilateral autosomal dominant optic nerve colobomas

Michael Moore, Danielle Salles, Lee Merrill Jampol*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

PURPOSE: To document progressive optic nerve cupping and neural rim decrease in a patient with normal intraocular pressures and bilateral autosomal dominant optic nerve colobomas. METHODS: The ophthalmology records, stereoscopic fundus photographs, and visual fields of a 27-year-old woman with familial (autosomal dominant) optic nerve colobomas were reviewed. The appearance of the optic nerves was documented over a 13-year period (1985 to 1998). RESULTS: Despite repeatedly normal intraocular pressures, the patient showed progressive optic nerve cupping and neural rim decrease in both eyes. Visual field testing was available over a 5-year period (1993 to 1998) and was abnormal, but no progression was seen. CONCLUSIONS: This case of progressive cupping and neural rim decrease in a patient with autosomal dominant optic nerve coloboma in both eyes may provide insight into the optic nerve cupping associated with normal tension glaucoma. Careful follow-up of patients with optic disk colobomas or patients is indicated to detect possible optic nerve changes or field loss. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)517-520
Number of pages4
JournalAmerican Journal of Ophthalmology
Volume129
Issue number4
DOIs
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Ophthalmology

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