Progressive osseous heteroplasia, uncommon cause of soft tissue ossification: A case report and review of the literature

R. Rodriguez-Jurado, F. Gonzalez-Crussi*, Andrew K Poznanski

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We report a case of an uncommon, recently described disease manifesting shortly after birth, characterized by extensive soft tissue calcification with ossification, progressive osseous heteroplasia. We describe the complex histopathologic patterns present in this case, discuss the main differential diagnoses that the surgical pathologist must consider when confronted by soft tissue ossification, and review the pertinent literature. We conclude that although the morphologic patterns of ossification in progressive osseous heteroplasia are complex and the involvement is extensive, the morphology of the lesions lacks diagnostic specificity. The diagnosis must be based on a consideration of the combined clinical data and radiologic and pathologic findings. This approach alone makes it possible to exclude a number of clinicopathologic entities that manifest with so-called osteoma cutis but whose associated lesions and genetic implications are different..

Original languageEnglish (US)
Pages (from-to)813-827
Number of pages15
JournalFetal and Pediatric Pathology
Volume15
Issue number5
DOIs
StatePublished - Jan 1 1995

Keywords

  • Calcification
  • Fibrodysplasia ossificans progressiva
  • Osteoma cutis
  • Progressive osseous heteroplasia
  • Soft tissue ossification

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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