Projection structure of a gap junction membrane channel at 7 Å resolution

V. M. Unger, N. M. Kumar, N. B. Gilula, M. Yeager*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Electron cryo-microscopy and image analysis of frozen-hydrated, two- dimensional crystals of gap junction membrane channels formed by recombinant α1 connexin (Cx43) reveal a ring of transmembrane α-helices that lines the aqueous pore and a second ring of α-helices in close contact with the membrane lipids.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalNature Structural Biology
Volume4
Issue number1
DOIs
StatePublished - Jan 18 1997

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

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