Prolactin response to morphine in depression

Alan G. Robertson*, Herbert Jackman, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The mean maximum prolactin response following administration of morphine sulfate, 5 mg, i.v., was significantly lower in 15 unmedicated inpatients with major depressive disorder than in 8 normal controls and 11 unmedicated inpatients with other psychiatric diagnoses. The maximum prolactin response of 8/15 depressed patients was less than the lowest response of any of the normal controls. Six of 15 depressed patients had blunted prolactin responses (less than 2 ng/ml) in the 60-minute sample. The diminished increase in serum prolactin after morphine in depressed patients may reflect anterior pituitary dysfunction or abnormalities in central endogenous opioid, dopamine, serotonin, or other neuroregulatory systems.

Original languageEnglish (US)
Pages (from-to)353-364
Number of pages12
JournalPsychiatry Research
Volume11
Issue number4
DOIs
StatePublished - Apr 1984

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Keywords

  • Morphine
  • major depressive disorder
  • prolactin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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