Prolactin responses to domperidone in chronic schizophrenia

Dina Nerozzi*, Armando Magnani, Corrado Dastoli, Edoardo Ferri, Giampiero Capesciotti, Italo Antonozzi, Gaetano Frajese, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The prolactin response to 20 mg of domperidone, a peripheral dopamine receptor antagonist, was evaluated in a group of 17 male, drug-free, elderly, chronic schizophrenic patients and 8 age-matched male normal control subjects. Both groups of subjects were receiving a variety of nonpsychotropic medications not known to affect the prolactin response to dopamine receptor antagonists. Basal plasma prolactin levels did not differ between the two groups. However, the prolactin response following domperidone was significantly greater in the schizophrenic patients, although plasma domperidone levels did not differ between the two groups. This effect is opposite to the previously reported effect of domperidone in young schizophrenic patients compared with age-matched control subjects (Nerozzi, 1990). The prolactin response to domperidone was markedly smaller in the old compared with the young normal control subjects, whereas the young and old schizophrenic patients had identical responses. Possible explanations for these results are considered, especially the possibility of abnormalities in the release of dopamine and pituitary D2 dopamine receptors in the elderly schizophrenic patients compared with age-matched normal control subjects.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalPsychiatry Research
Volume42
Issue number2
DOIs
StatePublished - May 1992

Keywords

  • D receptors
  • Psychoneuroendocrinology
  • age
  • domperidone
  • dopamine
  • pituitary hormones

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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