Proliferating cell nuclear antigen (PCNA): Ringmaster of the genome

T. Paunesku, S. Mittal, M. Protić, J. Oryhon, S. V. Korolev, A. Joachimiak, G. E. Woloschak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

263 Scopus citations

Abstract

Proliferating cell nuclear antigen (PCNA) protein is one of the central molecules responsible for decisions of life and death of the cell. The PCNA gene is induced by p53, while PCNA protein interacts with p53-controlled proteins Gadd45, MyD118, CR6 and, most importantly, p21, in the process of deciding cell fate. If PCNA protein is present in abundance in the cell in the absence of p53, DNA replication occurs. On the other hand, if PCNA protein levels are high in the cell in the presence of p53, DNA repair takes place. If PCNA is rendered non-functional or is absent or present in low quantities in the cell, apoptosis occurs. The evolution from prokaryotes to eukaryotes involved a change of function of PCNA from a 'simple' sliding clamp protein of the DNA polymerase complex to an executive molecule controlling critical cellular decision pathways. The evolution of multicellular organisms led to the development of multicellular processes such as differentiation, senescence and apoptosis. PCNA, already an essential molecule in the life of single cellular organisms, then became a protein critical for the survival of multicellular organisms.

Original languageEnglish (US)
Pages (from-to)1007-1021
Number of pages15
JournalInternational Journal of Radiation Biology
Volume77
Issue number10
DOIs
StatePublished - Oct 29 2001

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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