Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein

Cyrille Sage, Mingqian Huang, Kambiz Karimi, Gabriel Gutierrez, Melissa A. Vollrath, Duan Sun Zhang, Jaime García-Añoveros, Philip W. Hinds, Jeffrey T. Corwin, David P. Corey, Zheng Yi Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

In mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the retinoblastoma protein (pRb) as a candidate regulator of cell cycle exit in hair cells. Differentiated and functional mouse hair cells with a targeted deletion of Rb1 undergo mitosis, divide, and cycle, yet continue to become highly differentiated and functional. Moreover, acute loss of Rb1 in postnatal hair cells caused cell cycle reentry. Manipulation of the pRb pathway may ultimately lead to mammalian hair cell regeneration.

Original languageEnglish (US)
Pages (from-to)1114-1118
Number of pages5
JournalScience
Volume307
Issue number5712
DOIs
StatePublished - Feb 18 2005

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Retinoblastoma Protein
Cell Cycle
Alopecia
Gene Expression Profiling
Hearing Loss
Mitosis
Regeneration
Mammals

ASJC Scopus subject areas

  • General

Cite this

Sage, C., Huang, M., Karimi, K., Gutierrez, G., Vollrath, M. A., Zhang, D. S., ... Chen, Z. Y. (2005). Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science, 307(5712), 1114-1118. https://doi.org/10.1126/science.1106642
Sage, Cyrille ; Huang, Mingqian ; Karimi, Kambiz ; Gutierrez, Gabriel ; Vollrath, Melissa A. ; Zhang, Duan Sun ; García-Añoveros, Jaime ; Hinds, Philip W. ; Corwin, Jeffrey T. ; Corey, David P. ; Chen, Zheng Yi. / Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. In: Science. 2005 ; Vol. 307, No. 5712. pp. 1114-1118.
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abstract = "In mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the retinoblastoma protein (pRb) as a candidate regulator of cell cycle exit in hair cells. Differentiated and functional mouse hair cells with a targeted deletion of Rb1 undergo mitosis, divide, and cycle, yet continue to become highly differentiated and functional. Moreover, acute loss of Rb1 in postnatal hair cells caused cell cycle reentry. Manipulation of the pRb pathway may ultimately lead to mammalian hair cell regeneration.",
author = "Cyrille Sage and Mingqian Huang and Kambiz Karimi and Gabriel Gutierrez and Vollrath, {Melissa A.} and Zhang, {Duan Sun} and Jaime Garc{\'i}a-A{\~n}overos and Hinds, {Philip W.} and Corwin, {Jeffrey T.} and Corey, {David P.} and Chen, {Zheng Yi}",
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Sage, C, Huang, M, Karimi, K, Gutierrez, G, Vollrath, MA, Zhang, DS, García-Añoveros, J, Hinds, PW, Corwin, JT, Corey, DP & Chen, ZY 2005, 'Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein', Science, vol. 307, no. 5712, pp. 1114-1118. https://doi.org/10.1126/science.1106642

Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. / Sage, Cyrille; Huang, Mingqian; Karimi, Kambiz; Gutierrez, Gabriel; Vollrath, Melissa A.; Zhang, Duan Sun; García-Añoveros, Jaime; Hinds, Philip W.; Corwin, Jeffrey T.; Corey, David P.; Chen, Zheng Yi.

In: Science, Vol. 307, No. 5712, 18.02.2005, p. 1114-1118.

Research output: Contribution to journalArticle

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AU - Sage, Cyrille

AU - Huang, Mingqian

AU - Karimi, Kambiz

AU - Gutierrez, Gabriel

AU - Vollrath, Melissa A.

AU - Zhang, Duan Sun

AU - García-Añoveros, Jaime

AU - Hinds, Philip W.

AU - Corwin, Jeffrey T.

AU - Corey, David P.

AU - Chen, Zheng Yi

PY - 2005/2/18

Y1 - 2005/2/18

N2 - In mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the retinoblastoma protein (pRb) as a candidate regulator of cell cycle exit in hair cells. Differentiated and functional mouse hair cells with a targeted deletion of Rb1 undergo mitosis, divide, and cycle, yet continue to become highly differentiated and functional. Moreover, acute loss of Rb1 in postnatal hair cells caused cell cycle reentry. Manipulation of the pRb pathway may ultimately lead to mammalian hair cell regeneration.

AB - In mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the retinoblastoma protein (pRb) as a candidate regulator of cell cycle exit in hair cells. Differentiated and functional mouse hair cells with a targeted deletion of Rb1 undergo mitosis, divide, and cycle, yet continue to become highly differentiated and functional. Moreover, acute loss of Rb1 in postnatal hair cells caused cell cycle reentry. Manipulation of the pRb pathway may ultimately lead to mammalian hair cell regeneration.

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Sage C, Huang M, Karimi K, Gutierrez G, Vollrath MA, Zhang DS et al. Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science. 2005 Feb 18;307(5712):1114-1118. https://doi.org/10.1126/science.1106642