Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein

Cyrille Sage, Mingqian Huang, Kambiz Karimi, Gabriel Gutierrez, Melissa A. Vollrath, Duan Sun Zhang, Jaime García-Añoveros, Philip W. Hinds, Jeffrey T. Corwin, David P. Corey, Zheng Yi Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

207 Scopus citations

Abstract

In mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the retinoblastoma protein (pRb) as a candidate regulator of cell cycle exit in hair cells. Differentiated and functional mouse hair cells with a targeted deletion of Rb1 undergo mitosis, divide, and cycle, yet continue to become highly differentiated and functional. Moreover, acute loss of Rb1 in postnatal hair cells caused cell cycle reentry. Manipulation of the pRb pathway may ultimately lead to mammalian hair cell regeneration.

Original languageEnglish (US)
Pages (from-to)1114-1118
Number of pages5
JournalScience
Volume307
Issue number5712
DOIs
StatePublished - Feb 18 2005

ASJC Scopus subject areas

  • General

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