Prolonged coma from refractory status epilepticus

Saqib I. Dara, Lori A. Tungpalan, Edward M. Manno*, Vivien H. Lee, Kevin G. Moder, Mark T. Keegan, Jimmy R. Fulgham, Daniel R. Brown, Keith H. Berge, Francis X. Whalen, Tuhin K. Roy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objective: Status epilepticus is a life-threatening medical condition. In its most severe form, refractory status epilepticus (RSE) seizures may not respond to first and second-line anti-epileptic drugs. RSE is associated with a high mortality and significant medical complications in survivors with prolonged hospitalizations. Methods: We describe the clinical course of RSE in the setting of new onset lupus in a 31-year-old male who required prolonged barbiturate coma. Results: Seizure stopped on day 64 of treatment. Prior to the resolution of seizures, discussion around withdrawal of care took place between the physicians and patient's family. Medical care was continued because of the patient's age, normal serial MRI studies, and the patient's reversible medical condition. Conclusion: Few evidence-based data exist to guide management of RSE. Our case emphasizes the need for continuous aggressive therapy when neuroimaging remains normal.

Original languageEnglish (US)
Pages (from-to)140-142
Number of pages3
JournalNeurocritical Care
Issue number2
StatePublished - 2006


  • Barbiturate
  • Coma
  • Refractory status epilepticus (RSE)

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Clinical Neurology


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