Prolonged electrical stimulation over hip flexors increases locomotor output in human SCI

Ming Wu*, Keith Gordon, Jennifer H. Kahn, Brian D. Schmit

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: The objective of this study was to determine whether enhanced feedback from thigh afferents improves locomotor output in human spinal cord injury (SCI). Methods: The effects of afferent feedback originating from the upper thigh muscles on locomotion was examined using electrical stimulation in 10 subjects with incomplete SCI and three neurologically intact controls during robotic-assisted treadmill walking. Electrical stimulation consisted of 20 pulses at 30 Hz, applied bilaterally to the skin of the medial thigh, approximately over the sartorius muscle. The stimulation was applied at four different phases of the gait cycle. Torque responses of hip and knee joints and electromyograms of both legs were recorded during baseline with no stimulation, stimulation, and post-stimulation. Results: During stimulation, enhanced hip and knee extension and flexion torque responses were observed during the stance and swing phases, respectively, for all four different stimulation conditions. Larger hip extension torque was observed when the stimulation was applied during the stance phase and the transition from stance to swing. Conclusions: Enhanced afferent feedback produced by electrical stimulation may increase the excitability of the spinal cord locomotor circuits in human SCI. Significance: Results from this study emphasize the contribution of sensory information from thigh muscles, particularly the sartorius muscle afferents, to locomotor control in human SCI during treadmill walking.

Original languageEnglish (US)
Pages (from-to)1421-1428
Number of pages8
JournalClinical Neurophysiology
Volume122
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Thigh
Spinal Cord Injuries
Electric Stimulation
Hip
Torque
Muscles
Walking
Phase Transition
Hip Joint
Robotics
Electromyography
Locomotion
Knee Joint
Gait
Leg
Knee
Spinal Cord
Skin

Keywords

  • Electrical stimulation
  • Locomotion
  • Sensory afferents
  • Spinal cord injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

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title = "Prolonged electrical stimulation over hip flexors increases locomotor output in human SCI",
abstract = "Objectives: The objective of this study was to determine whether enhanced feedback from thigh afferents improves locomotor output in human spinal cord injury (SCI). Methods: The effects of afferent feedback originating from the upper thigh muscles on locomotion was examined using electrical stimulation in 10 subjects with incomplete SCI and three neurologically intact controls during robotic-assisted treadmill walking. Electrical stimulation consisted of 20 pulses at 30 Hz, applied bilaterally to the skin of the medial thigh, approximately over the sartorius muscle. The stimulation was applied at four different phases of the gait cycle. Torque responses of hip and knee joints and electromyograms of both legs were recorded during baseline with no stimulation, stimulation, and post-stimulation. Results: During stimulation, enhanced hip and knee extension and flexion torque responses were observed during the stance and swing phases, respectively, for all four different stimulation conditions. Larger hip extension torque was observed when the stimulation was applied during the stance phase and the transition from stance to swing. Conclusions: Enhanced afferent feedback produced by electrical stimulation may increase the excitability of the spinal cord locomotor circuits in human SCI. Significance: Results from this study emphasize the contribution of sensory information from thigh muscles, particularly the sartorius muscle afferents, to locomotor control in human SCI during treadmill walking.",
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Prolonged electrical stimulation over hip flexors increases locomotor output in human SCI. / Wu, Ming; Gordon, Keith; Kahn, Jennifer H.; Schmit, Brian D.

In: Clinical Neurophysiology, Vol. 122, No. 7, 01.07.2011, p. 1421-1428.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Wu, Ming

AU - Gordon, Keith

AU - Kahn, Jennifer H.

AU - Schmit, Brian D.

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AB - Objectives: The objective of this study was to determine whether enhanced feedback from thigh afferents improves locomotor output in human spinal cord injury (SCI). Methods: The effects of afferent feedback originating from the upper thigh muscles on locomotion was examined using electrical stimulation in 10 subjects with incomplete SCI and three neurologically intact controls during robotic-assisted treadmill walking. Electrical stimulation consisted of 20 pulses at 30 Hz, applied bilaterally to the skin of the medial thigh, approximately over the sartorius muscle. The stimulation was applied at four different phases of the gait cycle. Torque responses of hip and knee joints and electromyograms of both legs were recorded during baseline with no stimulation, stimulation, and post-stimulation. Results: During stimulation, enhanced hip and knee extension and flexion torque responses were observed during the stance and swing phases, respectively, for all four different stimulation conditions. Larger hip extension torque was observed when the stimulation was applied during the stance phase and the transition from stance to swing. Conclusions: Enhanced afferent feedback produced by electrical stimulation may increase the excitability of the spinal cord locomotor circuits in human SCI. Significance: Results from this study emphasize the contribution of sensory information from thigh muscles, particularly the sartorius muscle afferents, to locomotor control in human SCI during treadmill walking.

KW - Electrical stimulation

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