Abstract
Eight cases with stage IV allergic bronchopulmonary aspergillosis (ABPA) (corticosteroid-dependent asthma stage) were observed for a total of 82 patient years with individual patients observed for 7 to 19 years (mean 10.2) years. One case is the first case of ABPA diagnosed in the United States in 1967. A second case has been observed through four stages of ABPA. None of these eight cases has demonstrated pulmonary deterioration by clinical, chest roentgenogram, or pulmonary function analysis. After diagnosis, the maintenance dose of prednisone in seven of eight cases was a low to moderate dose alternate-day prednisone. These results suggest that continuous observation and management of episodes of pulmonary consolidation or asthma exacerbations may prevent the progression of ABPA to stage V (fibrotic end stage). The total IgE may remain elevated in these patients, and therapy should not attempt to reduce total serum IgE to normal levels. After prolonged therapy with prednisone for asthma and control of ABPA, the IgE and IgG antibody indices against Aspergillus fumigatus may remain elevated or may be below the levels that are of diagnostic value.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 663-668 |
| Number of pages | 6 |
| Journal | The Journal of allergy and clinical immunology |
| Volume | 80 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1987 |
Funding
From the Section of Allergy-Immunology, Departmentso f Me& tine and Pathology, Northwestern University Medical School, Chicago, Ill. Supportedb y United States Public Health Service Grant AI I1403 from the National Institute of Allergy and Infectious Diseases and The Ernest S. Bazley Grant. Received for publication Dec. I, 1986. Accepted for publication April 18, 1987. Reprint requests:R oy Patterson.M .D., 303 E. Chicago Ave., Chi-cago, IL 6061I .
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
