Prolonged norovirus infection after pancreas transplantation: A case report and review of chronic norovirus

I. A. Echenique, V. Stosor, L. Gallon, D. Kaufman, C. Qi, T. R. Zembower*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Norovirus is a major cause of self-limited gastroenteritis worldwide. Prevention and treatment are thwarted by rapid viral evolution, and thus supportive care remains the mainstay of therapy. Chronic infection in immunocompromised hosts is increasingly described. We report a case of norovirus infection lasting 2543 days in a pancreas transplant recipient. Serial fecal specimens were obtained, from which a map of genetic relatedness was derived. The clinical course was complicated by renal failure that progressed to end-stage renal disease. Minimization of immunosuppression was associated with resolution of the infection. Subsequently, the patient experienced a suspected allograft rejection that did not compromise pancreas function. The patient later underwent living-related renal transplantation without recurrence of enteritis.

Original languageEnglish (US)
Pages (from-to)98-104
Number of pages7
JournalTransplant Infectious Disease
Volume18
Issue number1
DOIs
StatePublished - Feb 1 2016

Keywords

  • Chronic diarrhea
  • Colitis
  • Diarrhea
  • End-stage renal disease
  • Gastroenteritis
  • Norovirus
  • Organ rejection
  • Pancreas transplant
  • Solid organ transplantation

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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