Prolonged survival of a patient with sickle cell trait and metastatic renal medullary carcinoma

Laura M. Pirich, Pauline Chou, David O. Walterhouse*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Purpose: The treatment and outcome of a patient with sickle cell trait and metastatic renal medullary carcinoma is described. Patient and Methods: A 12-year-old boy with sickle cell trait had metastatic renal medullary carcinoma. After surgical resection of the primary tumor, he received chemotherapy with methotrexate, vinblastine, doxorubicin, and cisplatin. The carcinoma progressed after a 6-month period of stable disease. At that time, he received chemotherapy including ifosfamide, etoposide, carboplatin, and topotecan. Results: The patient died of progressive disease 15 months from diagnosis. The patient's tumor in this report showed no progression while he was receiving methotrexate, vinblastine, doxorubicin, and cisplatin, but eventually became refractory to these and other cytotoxic agents. Conclusion: Renal medullary carcinoma is a highly chemotherapy-resistant tumor. Average survival after diagnosis is 15 weeks; the longest survival reported in the literature is 12 months from diagnosis. The patient in this report survived longer than the previously described patients before dying from progressive disease.

Original languageEnglish (US)
Pages (from-to)67-69
Number of pages3
JournalJournal of pediatric hematology/oncology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1999

Keywords

  • Chemotherapy
  • Renal medullary carcinoma
  • Sickle cell trait

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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