Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride

Dennis B. Solt*, Edmundo Cayama, Hiroyuki Tsuda, Katsuhiko Enomoto, George Lee, Emmanuel Farber

*Corresponding author for this work

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

Adult male Fischer rats were exposed to a necrogenic dose (200 mg/kg) of diethylnitrosamine or to nonnecrogenic doses of N-methyl-N-nitrosourea 1,2-dimethylhydrazine, or benzo-(a)pyrene following partial hepatectomy or sham hepatectomy. This treatment by itself led to no hepatocellular carcinomas by 8 to 18 months, except in animals given N-methyl-N-nitrosourea, which showed a 30% incidence by 12 months. With each treatment regimen, exposure to dietary 2-acetylaminofluorene for 2 weeks coupled with partial hepatectomy or the administration of a necrogenic dose of CCI4, was associated with an incidence of 68 to 94% of cancer at 8, 12, or 18 months, depending upon the initiating carcinogen used. Appropriate controls showed either no hepatocellular carcinoma or a much lower incidence. It is concluded that the 2-week exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or the administration of CCI4 has a strong promoting effect on liver carcinogenesis with four different chemical carcinogens.

Original languageEnglish (US)
Pages (from-to)188-191
Number of pages4
JournalCancer Research
Volume43
Issue number1
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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