Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease

Amir Ali Rahsepar, Hossein Pourghadamyari, Mohsen Moohebati, Seyyed Mohammad Reza Parizadeh, Shima Tavallaie, Roghayeh Paydar, Homa Falsoleiman, Mashalla Dehghani, Afsoon Fazlinezhad, Maral Amini, Fatemeh Khorashadizadeh, Majid Ghayour-Mobarhan*, Gordon A. Ferns

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects. Design and methods: Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD). Results: The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<. 0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>. 0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>. 0.05). Conclusions: In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.

Original languageEnglish (US)
Pages (from-to)1304-1308
Number of pages5
JournalClinical Biochemistry
Volume44
Issue number16
DOIs
StatePublished - Nov 2011

Keywords

  • Angiography
  • Coronary artery disease
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Biochemistry

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