TY - JOUR
T1 - Prooxidant-antioxidant balance and antioxidized LDL antibody level values and cardiac function in patients with coronary artery disease
AU - Rahsepar, Amir Ali
AU - Mirzaee, Asadollah
AU - Moodi, Fatemeh
AU - Moohebati, Mohsen
AU - Tavallaie, Shima
AU - Eshraghi, Ali
AU - Alavi, Maryam Sadat
AU - Khorashadizadeh, Fatemeh
AU - Pourghadamyari, Hossein
AU - Paydar, Roghayeh
AU - Amini, Maral
AU - Khojasteh, Roshanak
AU - Mousavi, Somayeh
AU - Sahebi, Maryam
AU - Ghayour-Mobarhan, Majid
AU - Ferns, Gordon A.A.
PY - 2012/9
Y1 - 2012/9
N2 - Objectives: We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD). Methods: Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients. Results: PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r =-0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05). Conclusion: Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.
AB - Objectives: We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD). Methods: Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients. Results: PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r =-0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05). Conclusion: Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.
KW - Antibody
KW - Antioxidized low-density lipoprotein
KW - Coronary artery disease
KW - Prooxidant-antioxidant balance
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U2 - 10.1159/000339273
DO - 10.1159/000339273
M3 - Article
C2 - 22854352
AN - SCOPUS:84864399174
SN - 0008-6312
VL - 122
SP - 203
EP - 209
JO - Cardiology (Switzerland)
JF - Cardiology (Switzerland)
IS - 4
ER -