Propranolol for proliferative diabetic retinopathy

Andrew M. Hendrick; Jeremy Arlin Lavine; Amitha Domalpally; Amol D. Kulkarni; Michael S. Ip

doi:10.3928/23258160-20171215-05

Propranolol for proliferative diabetic retinopathy

Andrew M. Hendrick^*, Jeremy Arlin Lavine, Amitha Domalpally, Amol D. Kulkarni, Michael S. Ip

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background and Objective: To determine the effect of propranolol on retinal neovascularization due to proliferative diabetic retinopathy (PDR). Patients and Methods: For this prospective pilot, interventional, case series, patients with diabetes with PDR (n = 10 subjects; 12 eyes) were recruited at the ophthalmology clinic of the University of Wisconsin - Madison. Subjects were administered oral propranolol for 12 weeks and retinopathy and area of retinal neovascularization were monitored with fundus photography and fluorescein angiography (FA). The study's main outcome measures were photographic area of retinal neovascularization and degree of leakage on FA. Results: All eyes demonstrated stable degrees of retinal neovascularization by the end of 12 weeks. Conclusion: This dose of oral propranolol during a period of 12 weeks did not demonstrate significant effect on retinal neovascularization due to PDR.

Original language	English (US)
Pages (from-to)	35-40
Number of pages	6
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	49
Issue number	1
DOIs	https://doi.org/10.3928/23258160-20171215-05
State	Published - Jan 2018

ASJC Scopus subject areas

Surgery
Ophthalmology

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title = "Propranolol for proliferative diabetic retinopathy",

abstract = "Background and Objective: To determine the effect of propranolol on retinal neovascularization due to proliferative diabetic retinopathy (PDR). Patients and Methods: For this prospective pilot, interventional, case series, patients with diabetes with PDR (n = 10 subjects; 12 eyes) were recruited at the ophthalmology clinic of the University of Wisconsin - Madison. Subjects were administered oral propranolol for 12 weeks and retinopathy and area of retinal neovascularization were monitored with fundus photography and fluorescein angiography (FA). The study's main outcome measures were photographic area of retinal neovascularization and degree of leakage on FA. Results: All eyes demonstrated stable degrees of retinal neovascularization by the end of 12 weeks. Conclusion: This dose of oral propranolol during a period of 12 weeks did not demonstrate significant effect on retinal neovascularization due to PDR.",

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note = "Funding Information: Originally submitted March 21, 2017. Revision received July 25, 2017. Accepted for publication September 20, 2017. This project was supported by an unrestricted departmental grant from Research to Prevent Blindness; an Emory Ophthalmology departmental core grant (NIH/NEI: P30 EY006360); and Clinical Research FA Davis Funds, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison. The sponsors had no role in the design or conduct of this research. Dr. Hendrick is a consultant for Clearside Biomedical. Dr. Ip is a consultant for Omeros, Thrombogenics, and Boehringer Ingelheim. The remaining authors report no relevant financial disclosures. Address correspondence to Andrew Hendrick, MD, Assistant Professor of Ophthalmology, Vitreoretinal Surgery and Diseases, 1365B Clifton Road NE, Atlanta, GA 30322; email: ahendrick@emory.edu. doi: 10.3928/23258160-20171215-05",

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N1 - Funding Information: Originally submitted March 21, 2017. Revision received July 25, 2017. Accepted for publication September 20, 2017. This project was supported by an unrestricted departmental grant from Research to Prevent Blindness; an Emory Ophthalmology departmental core grant (NIH/NEI: P30 EY006360); and Clinical Research FA Davis Funds, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison. The sponsors had no role in the design or conduct of this research. Dr. Hendrick is a consultant for Clearside Biomedical. Dr. Ip is a consultant for Omeros, Thrombogenics, and Boehringer Ingelheim. The remaining authors report no relevant financial disclosures. Address correspondence to Andrew Hendrick, MD, Assistant Professor of Ophthalmology, Vitreoretinal Surgery and Diseases, 1365B Clifton Road NE, Atlanta, GA 30322; email: ahendrick@emory.edu. doi: 10.3928/23258160-20171215-05

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N2 - Background and Objective: To determine the effect of propranolol on retinal neovascularization due to proliferative diabetic retinopathy (PDR). Patients and Methods: For this prospective pilot, interventional, case series, patients with diabetes with PDR (n = 10 subjects; 12 eyes) were recruited at the ophthalmology clinic of the University of Wisconsin - Madison. Subjects were administered oral propranolol for 12 weeks and retinopathy and area of retinal neovascularization were monitored with fundus photography and fluorescein angiography (FA). The study's main outcome measures were photographic area of retinal neovascularization and degree of leakage on FA. Results: All eyes demonstrated stable degrees of retinal neovascularization by the end of 12 weeks. Conclusion: This dose of oral propranolol during a period of 12 weeks did not demonstrate significant effect on retinal neovascularization due to PDR.

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Propranolol for proliferative diabetic retinopathy

Abstract

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