Abstract
Background and Objective: To determine the effect of propranolol on retinal neovascularization due to proliferative diabetic retinopathy (PDR). Patients and Methods: For this prospective pilot, interventional, case series, patients with diabetes with PDR (n = 10 subjects; 12 eyes) were recruited at the ophthalmology clinic of the University of Wisconsin - Madison. Subjects were administered oral propranolol for 12 weeks and retinopathy and area of retinal neovascularization were monitored with fundus photography and fluorescein angiography (FA). The study's main outcome measures were photographic area of retinal neovascularization and degree of leakage on FA. Results: All eyes demonstrated stable degrees of retinal neovascularization by the end of 12 weeks. Conclusion: This dose of oral propranolol during a period of 12 weeks did not demonstrate significant effect on retinal neovascularization due to PDR.
Original language | English (US) |
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Pages (from-to) | 35-40 |
Number of pages | 6 |
Journal | Ophthalmic Surgery Lasers and Imaging Retina |
Volume | 49 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2018 |
Funding
Originally submitted March 21, 2017. Revision received July 25, 2017. Accepted for publication September 20, 2017. This project was supported by an unrestricted departmental grant from Research to Prevent Blindness; an Emory Ophthalmology departmental core grant (NIH/NEI: P30 EY006360); and Clinical Research FA Davis Funds, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison. The sponsors had no role in the design or conduct of this research. Dr. Hendrick is a consultant for Clearside Biomedical. Dr. Ip is a consultant for Omeros, Thrombogenics, and Boehringer Ingelheim. The remaining authors report no relevant financial disclosures. Address correspondence to Andrew Hendrick, MD, Assistant Professor of Ophthalmology, Vitreoretinal Surgery and Diseases, 1365B Clifton Road NE, Atlanta, GA 30322; email: [email protected]. doi: 10.3928/23258160-20171215-05
ASJC Scopus subject areas
- Surgery
- Ophthalmology