Prospective evaluation of defibrillation threshold and postshock rhythm in young ICD recipients

Andrew E. Radbill*, John K. Triedman, Charles I. Berul, Edward P. Walsh, Mark E. Alexander, Gregory Webster, Frank Cecchin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Adaptation of implantable cardioverter defibrillator (ICD) systems to the needs of pediatric and congenital heart patients is problematic due to constraints of vascular and thoracic anatomy. An improved understanding of the defibrillation energy and postshock pacing requirements in such patients may help direct more tailored ICD therapy. We describe the first prospective evaluation of defibrillation threshold (DFT) and postshock rhythm in this population. Methods: We prospectively studied patients ≤60 kg at time of ICD intervention. DFTs were obtained using a binary search protocol with three VF inductions. Postshock pacing was programmed using a stepwise protocol, lowering the rate prior to each VF induction. Results: Twenty patients were enrolled: 11 had channelopathy, five congenital heart disease, and four cardiomyopathy. The median age was 16 years, median weight 48 kg. Twelve patients had a transvenous high-voltage coil; eight had pericardial +/-subcutaneous coil(s). Median DFT was 7 J (range 3-31 J); 19/20 patients had DFT ≤15 J and all patients <25 kg had DFT ≤9 J (n = 6). There was no difference in DFT between patients with transvenous versus pericardial +/-subcutaneous coils (median 7 J vs 6 J, P = 0.59). No patient with normal atrioventricular conduction prior to defibrillation required postshock pacing (n = 16). There were no adverse events. Conclusions: These data suggest that many pediatric ICD patients have low DFTs and adequate postshock escape rhythm. This may help determine appropriate parameters for future design of pediatric-specific ICDs. (PACE 2012;35:1487-1493)

Original languageEnglish (US)
Pages (from-to)1487-1493
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Volume35
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • implantable device-defibrillation
  • implantable devices-pacemaker-bradyarrhythmias
  • pediatrics-electrophysiology
  • pediatrics-implantable devices

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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