Radiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL: Étude prospective de phase II

Translated title of the contribution: Prospective study of accerelated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck

A. Zouhair*, P. A. Coucke, D. Azria, P. Pache, R. Stupp, R. Moeckli, R. O. Mirimanoff, M. Ozsahin

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose. - To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. - Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43-81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI) was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam RT 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. - According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0-16). No grade 4 toxicity was observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, and actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion. - The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fractions per week) is feasible with local control rates comparable to that of published data. Acute RT-related morbidity is acceptable.

Translated title of the contributionProspective study of accerelated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck
Original languageFrench
Pages (from-to)231-236
Number of pages6
JournalCancer/Radiotherapie
Volume7
Issue number4
DOIs
StatePublished - Aug 2003

Keywords

  • Acute side effects
  • Cancer of the head and neck
  • Postoperative accelerated RT

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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