To assess the potential efficacy of tocopherol (Vitamin E) treatment as prophylaxis for adriamycin cardiotoxicity, 16 patients were prospectively randomized to receive either no added treatment or tocopherol (1800 U/day) in addition to their adriamycin combination chemotherapy. The systolic time interval, used as an index of left ventricular function, deteriorated in 7/7 tocopherol-treated patients (mean increase = .060) and 7/9 controls (mean increase = .052). We conclude that tocopherol, at the dose used in this study, offered no protection from the progressive decline in cardiac function induced by adriamycin.
|Original language||English (US)|
|Number of pages||5|
|Journal||Current Therapeutic Research - Clinical and Experimental|
|Issue number||5 I|
|State||Published - Jan 1 1980|
ASJC Scopus subject areas
- Pharmacology (medical)