Prospective study of tocopherol prophylaxis for anthracycline cardiac toxicity

S. A. Weitzman; B. Lorell; R. W. Carey

Prospective study of tocopherol prophylaxis for anthracycline cardiac toxicity

S. A. Weitzman, B. Lorell, R. W. Carey

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

To assess the potential efficacy of tocopherol (Vitamin E) treatment as prophylaxis for adriamycin cardiotoxicity, 16 patients were prospectively randomized to receive either no added treatment or tocopherol (1800 U/day) in addition to their adriamycin combination chemotherapy. The systolic time interval, used as an index of left ventricular function, deteriorated in 7/7 tocopherol-treated patients (mean increase = .060) and 7/9 controls (mean increase = .052). We conclude that tocopherol, at the dose used in this study, offered no protection from the progressive decline in cardiac function induced by adriamycin.

Original language	English (US)
Pages (from-to)	682-686
Number of pages	5
Journal	Current Therapeutic Research - Clinical and Experimental
Volume	28
Issue number	5 I
State	Published - Jan 1 1980

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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abstract = "To assess the potential efficacy of tocopherol (Vitamin E) treatment as prophylaxis for adriamycin cardiotoxicity, 16 patients were prospectively randomized to receive either no added treatment or tocopherol (1800 U/day) in addition to their adriamycin combination chemotherapy. The systolic time interval, used as an index of left ventricular function, deteriorated in 7/7 tocopherol-treated patients (mean increase = .060) and 7/9 controls (mean increase = .052). We conclude that tocopherol, at the dose used in this study, offered no protection from the progressive decline in cardiac function induced by adriamycin.",

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N2 - To assess the potential efficacy of tocopherol (Vitamin E) treatment as prophylaxis for adriamycin cardiotoxicity, 16 patients were prospectively randomized to receive either no added treatment or tocopherol (1800 U/day) in addition to their adriamycin combination chemotherapy. The systolic time interval, used as an index of left ventricular function, deteriorated in 7/7 tocopherol-treated patients (mean increase = .060) and 7/9 controls (mean increase = .052). We conclude that tocopherol, at the dose used in this study, offered no protection from the progressive decline in cardiac function induced by adriamycin.

AB - To assess the potential efficacy of tocopherol (Vitamin E) treatment as prophylaxis for adriamycin cardiotoxicity, 16 patients were prospectively randomized to receive either no added treatment or tocopherol (1800 U/day) in addition to their adriamycin combination chemotherapy. The systolic time interval, used as an index of left ventricular function, deteriorated in 7/7 tocopherol-treated patients (mean increase = .060) and 7/9 controls (mean increase = .052). We conclude that tocopherol, at the dose used in this study, offered no protection from the progressive decline in cardiac function induced by adriamycin.

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