Abstract
To assess the potential efficacy of tocopherol (Vitamin E) treatment as prophylaxis for adriamycin cardiotoxicity, 16 patients were prospectively randomized to receive either no added treatment or tocopherol (1800 U/day) in addition to their adriamycin combination chemotherapy. The systolic time interval, used as an index of left ventricular function, deteriorated in 7/7 tocopherol-treated patients (mean increase = .060) and 7/9 controls (mean increase = .052). We conclude that tocopherol, at the dose used in this study, offered no protection from the progressive decline in cardiac function induced by adriamycin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 682-686 |
| Number of pages | 5 |
| Journal | Current Therapeutic Research - Clinical and Experimental |
| Volume | 28 |
| Issue number | 5 I |
| State | Published - Jan 1 1980 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)