Prospective study of tocopherol prophylaxis for anthracycline cardiac toxicity

S. A. Weitzman, B. Lorell, R. W. Carey

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


To assess the potential efficacy of tocopherol (Vitamin E) treatment as prophylaxis for adriamycin cardiotoxicity, 16 patients were prospectively randomized to receive either no added treatment or tocopherol (1800 U/day) in addition to their adriamycin combination chemotherapy. The systolic time interval, used as an index of left ventricular function, deteriorated in 7/7 tocopherol-treated patients (mean increase = .060) and 7/9 controls (mean increase = .052). We conclude that tocopherol, at the dose used in this study, offered no protection from the progressive decline in cardiac function induced by adriamycin.

Original languageEnglish (US)
Pages (from-to)682-686
Number of pages5
JournalCurrent Therapeutic Research - Clinical and Experimental
Issue number5 I
StatePublished - 1980

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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