Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow burn sepsis

Steve Santangelo, Margo Shoup, Richard L. Gamelli, Ravi Shankar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background: Although prostaglandin E2 (PGE2) has been shown to be immunosuppressive, its role in the development of specific bone marrow myeloid lineages after thermal injury and sepsis has yet to be elucidated. The purpose of this study was to demonstrate that alterations in bone marrow progenitor proliferation favoring monocytopoiesis in burn sepsis can be restored by blocking the cellular interactions of PGE2. Methods: A murine model of burn sepsis with and without treatment with SC-19220, a PGE2 receptor antagonist, was used to determine peripheral monocyte and neutrophil counts as well as the colony forming potential of colony-stimulating factor responsive bone marrow progenitors. Results: Burn sepsis augmented the growth of the early colony-forming unit granulocyte-macrophage and monocyte progenitors and the number of circulating monocytes, whereas granulocyte progenitors and circulating neutrophils demonstrated an opposite response. Treatment with SC-19220 nearly reversed these alterations. Conclusion: These data indicate that abrogating PGE2's actions during burn sepsis can restore the balance in bone marrow granulocyte and monocyte production, further consolidating the pivotal role PGE2 plays in the pathogenesis of burn sepsis.

Original languageEnglish (US)
Pages (from-to)826-831
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume48
Issue number5
StatePublished - May 2000

Keywords

  • Burn
  • Monocytopoiesis
  • PGE
  • SC-19220
  • Sepsis

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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