Prostaglandin levels: Predictors of indomethacin responsiveness

Cathy Hammerman*, William Zaia, Stuart Berger, Elene Strates, Abdul Aldousany

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Pretreatment plasma dilator prostaglandin levels were measured in 16 premature infants with patent ductus arteriosus in an attempt to correlate abnormally elevated levels with clinical responsiveness to indomethacin therapy. Nine of the 16 infants responded well to indomethacin, with complete disappearance of their murmurs by 48 h. Eight of these nine infants had elevated baseline 6 keto PGF1α levels (>500 pg/ml). In contrast, seven of the 16 infants did not respond to indomethacin, and six of these had 6 keto PGF1α within the normal range (<500 pg/ml). PGE2 levels varied in the same general direction, but lacked the specificity and sensitivity of the 6 keto PGF1α levels. Thus, 6 keto PGF1α levels seem to correlate with, and may eventually be helpful in predicting, clinical indomethacin responsiveness in the premature neonate with patency of the ductus arteriosus.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalPediatric Cardiology
Volume7
Issue number2
DOIs
StatePublished - Jun 1 1986

Keywords

  • 6 keto prostaglandin Fα
  • Indomethacin
  • Patent ductus arteriosus
  • Prostaglandin E

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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