Prostate cancer aggressiveness locus on chromosome 7q32 - q33 identified by linkage and allelic imbalance studies

Phillippa J. Neville, David V. Conti, Pamela L. Paris Howard Levin, William J. Catalona, Brian K. Suarez, John S. Witte, Graham Casey*

*Corresponding author for this work

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The biologic aggressiveness of prostate tumors is an important indicator of prognosis. Chromosome 7q32 - q33 was recently reported to show linkage to more aggressive prostate cancer, based on Gleason score, in a large sibling pair study. We report confirmation and narrowing of the linked region using finer-scale genotyping. We also report a high frequency of allelic imbalance (AI) defined within this locus in a series of 48 primary prostate tumors from men unselected for family history or disease status. The highest frequency of AI was observed with adjacent markers D7S2531 (52%) and D7S1804 (36%). These two markers delineated a common region of AI, with 24 tumors exhibiting interstitial AI involving one or both markers. The 1.1-Mb candidate region contains relatively few transcripts. Additionally, we observed positive associations between interstitial AI at D7S1804 and early age at diagnosis (P=.03) as well as a high combined Gleason score and tumor stage (P=.06). Interstitial AI at D7S2531 was associated with a positive family history of prostate cancer (P=.05). These data imply that we have localized a prostate cancer tumor aggressiveness loci to chromosome 7q32-q33 that is involved in familial and nonfamilial forms of prostate cancer.

Original languageEnglish (US)
Pages (from-to)424-431
Number of pages8
JournalNeoplasia
Volume4
Issue number5
DOIs
StatePublished - Jan 1 2002

Keywords

  • 7q
  • AI
  • Aggressive
  • Linkage
  • Prostate

ASJC Scopus subject areas

  • Cancer Research

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    Neville, P. J., Conti, D. V., Paris Howard Levin, P. L., Catalona, W. J., Suarez, B. K., Witte, J. S., & Casey, G. (2002). Prostate cancer aggressiveness locus on chromosome 7q32 - q33 identified by linkage and allelic imbalance studies. Neoplasia, 4(5), 424-431. https://doi.org/10.1038/sj.neo.7900254