Prostate cancer old problems and new approaches - Part I. epidemiology, incidence and genetic alterations

Kenneth V. Honn*, Amer Aref, Yong Q. Chen, Michael L. Cher, John D. Crissman, Jeffrey D. Forman, Xiang Gao, David Grignon, Maha Hussain, Arthur T. Porter, J. Edson Pontes, Isaac Powell, Bruce Redman, Wael Sakr, Richard Severson, Dean G. Tang, David P. Wood

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Rates of prostate cancer (PCa) have increased so dramatically over the last decade that the age adjusted incidence rate for PCa is now greater than that any other cancer among men in the United States. This review, published as a three part series, provides a state-of-art assessment of the PCa problem in its divergent aspects. Part 1 covers epidemiology, incidence and progression. Several epidemiological studies have demostrated that first degree male relatives of men with PCa are at increased risk of developing the disease. Familial and genetic factors as well as medical, anthropometric, dietary, hormonal and occupational factors involved in PCa are discussed. Postmortem examination of the prostate in men without evidence of PCa documented a high frequency of adenocarcinoma. Latent disease occurred as early as the second decade of life. Although there is no significant difference in incidence between Caucasian and African-American males, high grade prostatic intraepithelial neoplasia (HGPIN) is higher in the latter group. While dietary fat, androgens and certain environmental factors may be determinants for PCa, the exact mechanism of tumorigenesis is still relatively unknown. The current thinking of the role of genomic instability, chromosomal alterations, tumor suppressor genes and the androgen receptor are explored.

Original languageEnglish (US)
Pages (from-to)98-109
Number of pages12
JournalPathology & Oncology Research
Volume2
Issue number1-2
DOIs
StatePublished - Mar 1 1996

Keywords

  • epidemiology
  • genetics
  • incidence
  • progression
  • prostate cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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    Honn, K. V., Aref, A., Chen, Y. Q., Cher, M. L., Crissman, J. D., Forman, J. D., Gao, X., Grignon, D., Hussain, M., Porter, A. T., Pontes, J. E., Powell, I., Redman, B., Sakr, W., Severson, R., Tang, D. G., & Wood, D. P. (1996). Prostate cancer old problems and new approaches - Part I. epidemiology, incidence and genetic alterations. Pathology & Oncology Research, 2(1-2), 98-109. https://doi.org/10.1007/BF02893960