TY - JOUR
T1 - Prostate cancer risk alleles and their associations with other malignancies
AU - Cooper, Phillip R.
AU - McGuire, Barry B.
AU - Helfand, Brian T.
AU - Loeb, Stacy
AU - Hu, Qiaoyan
AU - Catalona, William J.
N1 - Funding Information:
Financial Support: This study was supported in part by the Urological Research Foundation, Prostate SPORE grant ( P50 CA90386-05S2 ), Robert H. Lurie Comprehensive Cancer Center grant ( P30 CA60553 ), and deCODE Genetics, Inc.
Funding Information:
Financial Disclosure: B. B. McGuire received a travelling scholarship from Ipsen, GSK, Pfizer, and M.E.D. Surgical; W. J. Catalona has received research support and honoraria from, and has been a consultant to, Beckman Coulter, has received research support from, and been a consultant to, deCODE Genetics; has been a consultant to Nanosphere; and has received research support from, and been a consultant to, OHMX.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2011/10
Y1 - 2011/10
N2 - Objective: To determine whether certain risk alleles are responsible for the relationship between prostate cancer (CaP) and other malignancies. CaP has been associated with other common malignancies. Recently, numerous single nucleotide polymorphisms (SNPs) have been associated with CaP susceptibility. Methods: We genotyped 1121 patients with CaP for 36 risk alleles known to be significantly associated with CaP susceptibility and determined their relationships to other malignancies in CaP probands and their first-degree relatives. Results: The most common other malignancies in the CaP probands were nonmelanoma skin cancer (13.6%), leukemia (7.3%), melanoma (3.9%), non-Hodgkin's lymphoma (0.7%), colorectal cancer (0.6%), and multiple myeloma (0.3%). Among the probands, a significantly increased frequency of leukemia was found in the carriers of SNP rs2736098 (5p15, P =.03) and melanoma in the carriers of either SNP rs1512268 (8p21, P =.006) or SNP rs5759167 (22q13, P =.02). Multiple myeloma was more common in carriers of SNP rs9364554 (6q25, P =.02). The probands who were carriers of SNP rs16901979 (8q24) were significantly more likely to report a family history of melanoma (P =.03), and the probands with a family history of multiple myeloma and non-Hodgkin's disease were significantly more likely to be carriers of SNP rs12621278 (2q31, P =.04) and rs6465657 (7q21, P =.02), respectively. Conclusion: Certain alleles associated with CaP susceptibility might be associated with an increased or a decreased risk of other malignancies in CaP probands and their first-degree relatives. Additional studies are warranted to examine the underlying mechanisms of these SNPs in CaP and other malignancies.
AB - Objective: To determine whether certain risk alleles are responsible for the relationship between prostate cancer (CaP) and other malignancies. CaP has been associated with other common malignancies. Recently, numerous single nucleotide polymorphisms (SNPs) have been associated with CaP susceptibility. Methods: We genotyped 1121 patients with CaP for 36 risk alleles known to be significantly associated with CaP susceptibility and determined their relationships to other malignancies in CaP probands and their first-degree relatives. Results: The most common other malignancies in the CaP probands were nonmelanoma skin cancer (13.6%), leukemia (7.3%), melanoma (3.9%), non-Hodgkin's lymphoma (0.7%), colorectal cancer (0.6%), and multiple myeloma (0.3%). Among the probands, a significantly increased frequency of leukemia was found in the carriers of SNP rs2736098 (5p15, P =.03) and melanoma in the carriers of either SNP rs1512268 (8p21, P =.006) or SNP rs5759167 (22q13, P =.02). Multiple myeloma was more common in carriers of SNP rs9364554 (6q25, P =.02). The probands who were carriers of SNP rs16901979 (8q24) were significantly more likely to report a family history of melanoma (P =.03), and the probands with a family history of multiple myeloma and non-Hodgkin's disease were significantly more likely to be carriers of SNP rs12621278 (2q31, P =.04) and rs6465657 (7q21, P =.02), respectively. Conclusion: Certain alleles associated with CaP susceptibility might be associated with an increased or a decreased risk of other malignancies in CaP probands and their first-degree relatives. Additional studies are warranted to examine the underlying mechanisms of these SNPs in CaP and other malignancies.
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U2 - 10.1016/j.urology.2011.05.035
DO - 10.1016/j.urology.2011.05.035
M3 - Article
C2 - 21820706
AN - SCOPUS:80053918499
SN - 0090-4295
VL - 78
SP - 970.e15-970.e20
JO - Urology
JF - Urology
IS - 4
ER -
