Prostate-specific antigen screening: Pro

Stacy Loeb*, William J. Catalona

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Purpose of Review: Prostate cancer is the most common noncutaneous malignancy among men in the USA and is most frequently diagnosed through prostate-specific antigen (PSA)-based screening. Nevertheless, PSA testing has become increasingly controversial. In this review, we will present the evidence supporting the role of PSA in prostate cancer screening. Recent Findings: Numerous studies have shown that the risk of current and future prostate cancer is directly related to the serum PSA level. Moreover, increasing PSA levels predict a greater risk of adverse pathologic features and worse disease-specific survival. Substantial epidemiologic evidence has suggested a reduction in advanced disease and improvements in prostate cancer survival rates since the introduction of PSA-based screening. Recently, evidence from a randomized trial further validated that PSA testing reduces both metastatic disease and prostate cancer-specific mortality. Summary: PSA is a valid marker for prostate cancer and its aggressiveness. Level 1 evidence is now available that PSA-based screening reduces both the rate of metastatic disease and prostate cancer-specific mortality.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalCurrent Opinion in Urology
Volume20
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • Detection
  • Prostate cancer
  • Prostate-specific antigen
  • Screening

ASJC Scopus subject areas

  • Urology

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